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First Online: 25 April 2019

Compliance with ethical guidelines

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: G. Reifenberger has received research funding from Roche and Merck as well as fees for lectures or consulting activities from AbbVie. B. Malzkorn declares that he has no conflicts of interest.

: The tissue samples used for the histological images in Figs. InternalRef removed and InternalRef removed were retrieved from the archive of the Institute of Neuropathology at Heinrich Heine University Düsseldorf. The use of archival samples for research purposes was approved by the Ethics Commission of the Medical Faculty of the Heinrich Heine University Düsseldorf (Study No. 3562).

: The supplement containing this article is not sponsored by industry.