Bethke, Anne http://orcid.org/0000-0001-7419-1899
Shanmuganathan, Limalanathan
Andersen, Geir Øystein
Eritsland, Jan
Swanson, David
Kløw, Nils Einar
Hoffmann, Pavel
Article History
Received: 13 March 2018
Revised: 9 May 2018
Accepted: 4 June 2018
First Online: 6 July 2018
Compliance with ethical standards
:
: The scientific guarantor of this publication is Pavel Hoffmann.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors, David Swanson, has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: Several articles on the cohort of patients included in the POSTEMI trial have been published [1-5]. The results reported were mainly clinical and biochemical endpoints. CMR results reported were infarct size, left ventricular function, microvascular obstruction, area at risk and myocardial salvage. Data on CMR first-pass perfusion have not been published yet.1. Limalanathan S, Eritsland J, Andersen GO, Klow NE, Abdelnoor M, Hoffmann P (2013) Myocardial salvage is reduced in primary PCI-treated STEMI patients with microvascular obstruction, demonstrated by early and late CMR. PLoS One 8 (8):e71780. doi:10.1371/journal.pone.00717802. Limalanathan S, Andersen GO, Klow NE, Abdelnoor M, Hoffmann P, Eritsland J (2014) Effect of ischemic postconditioning on infarct size in patients with ST-elevation myocardial infarction treated by primary PCI results of the POSTEMI (POstconditioning in ST-Elevation Myocardial Infarction) randomized trial. J Am Heart Assoc 3 (2):e000679. doi:10.1161/JAHA.113.0006793. Limalanathan S, Eritsland J, Klow NE, Abdelnoor M, Hoffmann P, Andersen GO (2015) Influence of ischemic postconditioning on myocardial dysfunction measured by speckle tracking echocardiography in patients with ST-elevation myocardial infarction. Int J Cardiol 187:459-461. doi:10.1016/j.ijcard.2015.03.1924. Shetelig C, Limalanathan S, Eritsland J, Hoffmann P, Seljeflot I, Gran JM, Aukrust P, Ueland T, Andersen GO (2017) Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function. PLoS One 12 (3):e0173034. doi:10.1371/journal.pone.01730345. Ritschel V, Shetelig C, Seljeflot I, Limalanathan S, Hoffmann P, Halvorsen S, Arnesen H, Eritsland J, Andersen GO (2017) Evaluation of circulating levels of CCN2/connective tissue growth factor in patients with ST-elevation myocardial infarction. Sci Rep 7 (1):11945. doi:10.1038/s41598-017-12372-w
: • prospective• randomized controlled trial• performed at one institution