Erdur, Hebun http://orcid.org/0000-0001-5383-9625
Milles, Lennart S.
Scheitz, Jan F.
Villringer, Kersten
Haeusler, Karl Georg
Endres, Matthias
Audebert, Heinrich J.
Fiebach, Jochen B.
Nolte, Christian H.
Article History
Received: 7 May 2018
Revised: 9 July 2018
Accepted: 27 July 2018
First Online: 23 August 2018
Compliance with ethical standards
:
: The scientific guarantor of this publication is Dr. Hebun Erdur.
: The authors of this manuscript declare relationships with the following companies:Dr. Hebun Erdur, Dr. Lennart S Milles, and PD Dr. Jan F Scheitz report no disclosures. Dr. Kersten Villringer reports receiving consulting fees by Parexel and is supported by the Federal Ministry of Education and Research via the grant Centre for Stroke Research Berlin (01EO0801 and 01EO01301). PD Dr. Karl-Georg Häusler has received grant support by Bayer and speaker/consultancy honoraria from Boehringer Ingelheim, Bayer Healthcare, Sanofi, Daiichi-Sankyo, Pfizer, Bristol-Myers-Squibb and Medtronic. Prof. Dr. Matthias Endres receives funding from the Deutsche Forschungsgemeinschaft (Excellence cluster NeuroCure; SFB TR43, KFO 247, KFO 213), Bundesministerium für Bildung und Forschung (Centre for Stroke Research Berlin), European Union (European Stroke Network, Wake-Up, Counterstroke), and Volkswagen Foundation (Lichtenberg Program) and reports advisory board and lecture fees paid to the Charité from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Ever, Glaxo Smith Kline, Novartis, Pfizer, and Sanofi. Prof. Dr. Heinrich J Audebert has received grant support (by Pfizer) and speaker/consultancy honoraria from Boehringer Ingelheim, Bayer Healthcare, Sanofi, Daiichi-Sankyo, Pfizer, Bristol-Myers-Squibb, ReNeuron and EVER Neuropharma. Prof. Dr. Jochen B Fiebach has received consulting, lecture, and advisory board fees from BioClinica, Cerevast, Artemida, Brainomix, and Lundbeck as well as a grant from the German Federal Ministry of Education and Research (01EO0801 and 01EO01301). As PI he receives funding from the European Union Seventh Framework Program [FP7/2007–2013] under grant agreement no. 278276 (WAKE-UP). Prof. Dr. Christian H Nolte has received funding for travel or speaker honoraria or consultancies from Bayer, Boehringer Ingelheim, Gore, Sanofi and BMS/Pfizer.
: Dr. Hebun Erdur and Prof. Dr. Christian H Nolte have significant statistical expertise. No complex statistical methods were necessary for this paper.
: Written informed consent was not required for this study in accordance with laws and regulations in the Federal State of Berlin.
: Institutional Review Board approval was obtained for the prospective 1000+ study (Institutional Review Board number EA4/026/08). An ethics committee approval was not required for the current substudy, in accordance with laws and regulations in the Federal State of Berlin.
: • Retrospective• Observational• Performed at one institution