Funding for this research was provided by:
National Institute for Health Research (NIHR-PDF 2011-04-51 Gerald P McCann)
Text and Data Mining valid from 2018-11-28
Received: 14 May 2018
Revised: 3 August 2018
Accepted: 19 September 2018
First Online: 28 November 2018
Compliance with ethical standards
: The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health, UK.
: The scientific guarantor of this publication is Professor Gerry McCann.
: MAH is the owner of Xinapse Systems software which was used to quantify distensibility and PWV in this study. There are no other competing interests to declare.
: No complex statistical methods were necessary for this paper.
: Written informed consent was obtained from all subjects before participation.
: The study was approved by the United Kingdom National Research Ethics Service (11/EM/0410).
: Some study subjects have been previously reported in the main results of the PRIMID-AS study (as mentioned in reference 15 under the “InternalRef removed” section of the manuscript). However, the aortic stiffness parameters are novel in this manuscript, as is the comparison of bicuspid and tricuspid sub-groups.
: • Prospective• Multi-centre• Observational study