Funding for this research was provided by:
University of Glasgow
Text and Data Mining valid from 2019-03-27
Received: 31 January 2019
Revised: 17 February 2019
Accepted: 7 March 2019
First Online: 27 March 2019
Compliance with ethical standards
: The scientific guarantor of this publication is Professor Patrick Mark.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was not required because this dose-finding study was performed to optimise our currently used protocol. This was approved by the Clinical Governance Committee of the Diagnostics Directorate of NHS Greater Glasgow & Clyde. The West of Scotland Research Ethics Committee ethics officer was consulted and confirmed that formal ethical committee approval was not required.
: • prospective• experimental• performed at one institution