Uthoff, Johanna
,
Koehn, Nicholas
Larson, Jared
Dilger, Samantha K. N.
Hammond, Emily
Schwartz, Ann
Mullan, Brian
Sanchez, Rolando
Hoffman, Richard M.
Sieren, Jessica C.
Funding for this research was provided by:
American Cancer Society (IGR-77-004-34)
National Heart, Lung, and Blood Institute (U01-HL089897, U01HL089856)
National Institutes of Health (R01CA141769, P30CA022453, HHSN261201300011I)
Article History
Received: 18 October 2018
Revised: 6 February 2019
Accepted: 14 March 2019
First Online: 1 April 2019
Compliance with ethical standards
:
: The scientific guarantor of this publication is Dr. Jessica C. Sieren.
: The authors declare that they have no conflict of interest.
: The first and last authors, as biomedical engineers, have experience with biostatistics methods. No complex statistical methods were necessary for this paper.
: The University of Iowa Institutional Review Board has approved this study (IRB 201603824). Informed consent was obtained from the research cohort participants through the parent studies, COPDgene and INHALE (including the approval of collected data for expanded research questions beyond the parent study purpose). For the retrospective clinical cohort, written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained.
: Forty subjects from study subjects or cohorts have been previously reported by our lab in a machine learning approach development [CitationRef removed, CitationRef removed, CitationRef removed].
: • Retrospective• observational• performed at one institution