Reiter, Rolf http://orcid.org/0000-0002-9741-6736
Tzschätzsch, Heiko
Schwahofer, Florian
Haas, Matthias
Bayerl, Christian
Muche, Marion
Klatt, Dieter
Majumdar, Shreyan
Uyanik, Meltem
Hamm, Bernd
Braun, Jürgen
Sack, Ingolf
Asbach, Patrick
Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (RE 4161/1-1, RE 4161/1-2, SFB 1340/1 Matrix in Vision, SFB 1340/1 Matrix in Vision, SFB 1340/1 Matrix in Vision)
Deutsche Forschungsgemeinschaft (SFB 1340/1 Matrix in Vision)
Article History
Received: 16 July 2019
Revised: 23 August 2019
Accepted: 19 September 2019
First Online: 11 November 2019
Compliance with ethical standards
:
: The scientific guarantor of this publication is Rolf Reiter, MD.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: Meltem Uyanik, MS, from the Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA, kindly provided statistical advice and is one of the co-authors of this manuscript.
: Written informed consent was obtained from all subjects in this study.
: Institutional Review Board approval was obtained.
: Some study subjects (healthy volunteers) have been previously reported (Reiter R, Wetzel M, Hamesch K, et al (2018) Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE). PLOS ONE. DOI:10.1371/journal.pone.0196486.) The same MR elastography raw data were acquired for all healthy volunteers in both studies; however, there are differences in the analyzed frequency range (30–60 Hz vs 35–60 Hz) and the postprocessing pipeline. There is no subject overlap in the patient population as our prior study only investigated patients with alpha1-antitrypsin deficiency–based liver fibrosis without biopsy.
: • prospective• diagnostic accuracy study and experimental• performed at one institution