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Article History

Received: 27 May 2019

Revised: 18 September 2019

Accepted: 14 October 2019

First Online: 10 December 2019

Compliance with ethical standards

:

: The scientific guarantor of this publication is Gert J. Meijer (g.j.meijer@umcutrecht.nl).

: The authors declare that they have no conflict of interest.

: Three of the authors have significant statistical expertise: A.S. Borggreve, L. Goense, and P.S.N. van Rossum hold a postgraduate master’s degree in epidemiology from Utrecht University, specializing in clinical epidemiology and medical statistics.

: Written informed consent was obtained from all patients in this study.

: Institutional Review Board approval was obtained.

: Some study subjects or cohorts have been previously reported in Heethuis et al (Quantification of variations in intra-fraction motion of esophageal tumors over the course of neoadjuvant chemoradiotherapy based on cine-MRI. Phys Med Biol.;63(14):145019) and Boekhoff et al (PO-0951: what CTV-to-PTV margins are required for esophageal cancer radiotherapy? Radiother Oncol. 2018;127:S519–S520). The current study was a prespecified secondary analysis and reported on a completely different outcome (histopathological tumor regression) and used different MR scans (DW-MRI instead of anatomical T2W MRI) than the previous studies.

: • prospective• observational study• performed at one institution