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Article History

Received: 26 November 2019

Revised: 3 June 2020

Accepted: 10 August 2020

First Online: 9 September 2020

Compliance with ethical standards

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: The scientific guarantor of this publication is Prof. Marc Dewey.

: Sarah Feger: Dr. Feger reports grants from European Commission, other from Vital Images, other from AG Mednet, during the conduct of the study; grants from Siemens Medical Solutions; grants from GE Healthcare; grants from Toshiba Medical Systems; and grants from Philips Medical Systems, outside the submitted work.Paolo Ibes: Dr. Ibes reports grants and other from European Commission, from Vital Images, and from AG Mednet, during the conduct of the study; grants from Siemens Medical Solutions; grants from GE Healthcare; grants from Toshiba Medical Systems; and grants from Philips Medical Systems, outside the submitted work.Adriane E. Napp: Dr. Napp reports grants from European Commission, other from Vital Images, and other from AG Mednet, during the conduct of the study; grants from Siemens Medical Solutions; grants from GE Healthcare; grants from Toshiba Medical Systems; and grants from Philips Medical Systems, outside the submitted work.Alexander Lembcke: Dr. Lembcke reports grants from European Commission, other from Vital Images, and other from AG Mednet, during the conduct of the study; grants from Siemens Medical Solutions; grants from GE Healthcare; grants from Toshiba Medical Systems; grants from Philips Medical Systems, and personal fees from PAREXEL International GmbH, outside the submitted work.Michael Laule: Dr. Laule has nothing to disclose.Henryk Dreger: Dr. Dreger has nothing to disclose.Björn Bokelmann: Mr. Bokelmann reports grants from European Commission, other from Vital Images, and other from AG Mednet, during the conduct of the study; grants from Siemens Medical Solutions; grants from GE Healthcare; grants from Toshiba Medical Systems; and grants from Philips Medical Systems, outside the submitted work.Gershan K. Davis: Dr. Davis reports grants from the European Commission, during the conduct of the study.Giles Roditi: Dr. Roditi reports grants from the European Commission, during the conduct of the study.Ignacio Diez: Dr. Diez Gonzalez reports grants from the European Commission, during the conduct of the study.Stephen Schröder: Dr. Schröder reports grants from the European Commission, during the conduct of the study.Fabian Plank: Dr. Plank reports grants from the European Commission, during the conduct of the study.Pal Maurovich-Horvat: Dr. Maurovich-Horvat reports grants from the European Commission, during the conduct of the study.Radosav Vidakovic: Dr. Vidakovic reports grants from the European Commission, during the conduct of the study.Josef Veselka: Dr. Veselka reports grants from the European Commission, during the conduct of the study.Malgorzata Ilnicka-Suckiel: Dr. Ilnicka-Suckiel reports grants from the European Commission, during the conduct of the study.Andrejs Erglis: Dr. Erglis reports grants from European Commission, during the conduct of the study; grants from Abbott Vascular; grants from Boston Scientific; personal fees from Abbott Vascular; personal fees from Boston Scientific; personal fees from Biotronik; personal fees from Biosensors; personal fees from Cordis; and personal fees from Medtronik, outside the submitted work.Teodora Benedek: Dr. Benedek reports grants from European Commission, during the conduct of the study; grants from Romanian Ministry of European Funds; the Romanian Government and the European Union; and grants from Romanian Ministry of European Funds, the Romanian Government, and the European Union, outside the submitted work.José Rodriguez-Palomares: Dr. Rodriguez-Palomares reports grants from the European Commission, during the conduct of the study.Luca Saba: Dr. Saba reports grants from the European Commission, during the conduct of the study; personal fees from Springer; and personal fees from Francis and Taylor, outside the submitted work.Klaus Kofoed: Dr. Fuglsang Kofoed reports grants from European Commission, during the conduct of the study; grants from AP Møller og hustru Chastine McKinney Møllers Fond; grants from The John and Birthe Meyer Foundation; grants from Research Council of Rigshopitalet; grants from The University of Copenhagen; grants from The Danish Heart Foundation; grants from The Lundbeck Foundation; grants from The Danish Agency for Science, Technology and Innovation by The Danish Council for Strategic Research; grants from CATCH-2 trial; grants from CSub320 trial; and grants from Toshiba Medical Corporation, other from Toshiba Medical Corporation, outside the submitted work.Matthias Gutberlet: Dr. Gutberlet reports grants from European Commission, during the conduct of the study; grants from Bayer Healthcare; grants and other from Bayer Healthcare; grants from Bracco; and grants from Philips; other from Philips Medical Systems, from Siemens Medical Solutions, other from Siemens Medical Solutions, outside the submitted work.Filip Ađić: Dr. Ađić reports grants from the European Commission, during the conduct of the study.Mikko Pietilä: Dr. Pietila reports grants from European Commission, during the conduct of the study; personal fees from AstraZeneca, personal fees from Novartis, personal fees from MSD, non-financial support from Bayer, and non-financial support from B. Braun, outside the submitted work.Rita Faria: Dr. Faria reports grants from the European Commission, during the conduct of the study; other from the Portuguese Ministry of Health, outside the submitted work.Audronė Vaitiekienė Dr. Vaitiekiene reports grants from the European Commission, during the conduct of the study.Jonathan Dodd: Dr. Dodd reports grants from European Commission, during the conduct of the study; personal fees from co-author of the StatDx Cardiovascular textbook, 2nd Ed; other from Associate editor for Radiology, European Radiology, QJM and Respirology, outside the submitted work.Patrick Donnelly: Dr. Donnelly reports grants from the European Commission, during the conduct of the study; grants from Southeastern Health and Social Care Trust Innovation Research Development Group Fund, outside the submitted work.Marco Francone: Dr. Francone reports grants from the European Commission, during the conduct of the study; personal fees from Bayer Medical Imaging and personal fees from Bracco, outside the submitted work.Cezary Kepka: Dr. Kepka reports grants from the European Commission, during the conduct of the study.Balazs Ruzsics: Dr. Ruzsics reports grants from the European Commission, during the conduct of the study.Jacqueline Müller-Nordhorn: Dr. Müller-Nordhorn reports grants from the European Commission, during the conduct of the study.Peter Schlattmann: Dr. Schlattmann reports grants from the European Commission, during the conduct of the study.Marc Dewey: Dr. Dewey reports grants from the European Commission, other from Vital Images, other from AG Mednet, during the conduct of the study; grants from Siemens Medical Solutions; grants from GE Healthcare; grants from Toshiba Medical Systems; grants from Philips Medical Systems; and grants from Heisenberg Programme of DFG, outside the submitted work.

: One of the authors (PM) has significant statistical expertise.

: Depending on local site requirements for data acquisition, written and/or oral informed consent was obtained from all patients participating in the DISCHARGE pilot study. The study participants did not undergo any follow-up examinations or investigational procedures.

: The ethics approval for the main DISCHARGE trial (EA1/294/13) included the pilot study.

: • prospective• non-randomised clinical trial• multicenter study