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Article History

Received: 18 June 2020

Revised: 5 August 2020

Accepted: 15 September 2020

First Online: 1 October 2020

Compliance with ethical standards

:

: The scientific guarantor of this publication is Juan Miguel García Gómez, full professor at Universitat Politècnica de València (juanmig@upv.es).

: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

: No complex statistical methods were necessary for this paper.

: Written informed consent was waived by the Institutional Review Board.

: Institutional Review Board approval was obtained. A material transfer agreement was approved by all the participating centers and an acceptance report was issued by the Ethical Committee of each center. The Universitat Politècnica de València institutional ethical board also approved this retrospective study.

: Some study subjects or cohorts have been previously reported in [].In the present study, we used a subset of the NCT03439332 multicenter study cohort. The NCT03439332 cohort was used in [] to validate the primary endpoint of the NCT03439332 study, which is to validate the robust association between vascular habitats and patient prognosis in glioblastoma. In the present study, however, we use a subset of these data to study the joint influence of vascularity, estimated by perfusion MRI, and MGMT methylation on the survival of patients with GBM. MGMT methylation was not considered in the study of Álvarez-Torres et al []; moreover, the objective, results, and conclusions do not overlap between the current and previous studies.[] Álvarez-Torres MDM, Juan-Albarracín J, Fuster-Garcia E, et al (2019) Robust association between vascular habitats and patient prognosis in glioblastoma: an international multicenter study<i>. J Magn Reson Imaging</i>.

: •retrospective•observational•multicenter study