Fuster-Garcia, Elies http://orcid.org/0000-0002-0716-8960
Lorente Estellés, David
Álvarez-Torres, María del Mar
Juan-Albarracín, Javier
Chelebian, Eduard
Rovira, Alex
Acosta, Cristina Auger
Pineda, Jose
Oleaga, Laura
Mollá-Olmos, Enrique
Filice, Silvano
Due-Tønnessen, Paulina
Meling, Torstein R.
Emblem, Kyrre E.
García-Gómez, Juan M.
Funding for this research was provided by:
Secretaría de Estado de Investigación, Desarrollo e Innovación (DPI2016-80054-R)
H2020 Health (727560, 825750)
H2020 European Research Council (758657)
Helse Sør-Øst RHF (2017073, 2013069)
Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+I (DPI2016-80054-R)
H2020 Marie Skłodowska-Curie Actions (844646)
Article History
Received: 18 June 2020
Revised: 5 August 2020
Accepted: 15 September 2020
First Online: 1 October 2020
Compliance with ethical standards
:
: The scientific guarantor of this publication is Juan Miguel García Gómez, full professor at Universitat Politècnica de València (juanmig@upv.es).
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: No complex statistical methods were necessary for this paper.
: Written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained. A material transfer agreement was approved by all the participating centers and an acceptance report was issued by the Ethical Committee of each center. The Universitat Politècnica de València institutional ethical board also approved this retrospective study.
: Some study subjects or cohorts have been previously reported in [CitationRef removed].In the present study, we used a subset of the NCT03439332 multicenter study cohort. The NCT03439332 cohort was used in [CitationRef removed] to validate the primary endpoint of the NCT03439332 study, which is to validate the robust association between vascular habitats and patient prognosis in glioblastoma. In the present study, however, we use a subset of these data to study the joint influence of vascularity, estimated by perfusion MRI, and MGMT methylation on the survival of patients with GBM. MGMT methylation was not considered in the study of Álvarez-Torres et al [CitationRef removed]; moreover, the objective, results, and conclusions do not overlap between the current and previous studies.[CitationRef removed] Álvarez-Torres MDM, Juan-Albarracín J, Fuster-Garcia E, et al (2019) Robust association between vascular habitats and patient prognosis in glioblastoma: an international multicenter study<i>. J Magn Reson Imaging</i>. ExternalRef removed
: •retrospective•observational•multicenter study