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Article History

Received: 7 August 2020

Revised: 24 December 2020

Accepted: 27 January 2021

First Online: 10 February 2021

Compliance with ethical standards

:

: The scientific guarantor of this publication is Dr Doenja MJ Lambregts.

: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

: One of the authors, Mr Sander Roberti, has significant statistical expertise.

: Written informed consent was waived by the Institutional Review Boards (retrospective analysis of prospectively obtained observational data).

: Institutional Review Board approval was obtained.

: Some study subjects or cohorts have been previously reported in:Schurink (2020) <i>Eur Radiol</i>Curvo-Semedo (2011) <i>Radiol</i>Van Stiphout (2014) <i>Radiother Oncol</i>Janssen (2012) <i>Int J Rad Oncol Biol Phys</i>Van Stiphout (2011) <i>Radiother Oncol</i>Janssen (2010) <i>Int J Rad Oncol Biol Phys</i>Janssen (2010) <i>Radiother Oncol</i>Lambregts (2011) <i>Ann Surg Oncol</i>Lambregts (2015) <i>Ann Surg</i>Martens (2015) <i>Int J Radiat Oncol Biol Phys</i>Lambregts (2018) <i>Dis Colon Rectum</i>

: • retrospective• diagnostic/prognostic• performed at one institution