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Authors
Vande Walle, Caroline https://orcid.org/0000-0002-5063-5376
Keymeulen, Annelies
Schiettecatte, Eva
Acke, Frederic
Dhooge, Ingeborg
Smets, Koenraad
Herregods, Nele
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Article History
Received: 22 October 2020
Revised: 8 January 2021
Accepted: 11 February 2021
First Online: 31 March 2021
Declarations
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: The scientific guarantor of this publication is Caroline Vande Walle, MD.
: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.No complex statistical methods were necessary for this paper.
: Written informed consent was obtained from the legal guardians of all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: Some study subjects or cohorts have been previously reported in:<i>Craeghs L., Goderis J. et al (2020) Congenital CMV-Associated Hearing Loss: Can Brain Imaging Predict Hearing Outcome? Ear Hear. 2020 Aug 3. doi: 10.1097/AUD.0000000000000927.</i>We estimate 168 patients of our study have been reported in the previously mentioned study.The patients in both studies were all enrolled in the “Flanders Congenital cytomegalovirus infection registry.” In the previously mentioned study, patients from the different investigation sites were used to investigate a possible association between imaging abnormalities and hearing outcome. Both ultrasound and MRI imaging features were described. As this was mainly a clinically oriented study, the brain abnormalities were derived from the retrospective review of the imaging reports (from different radiologists in different investigation centers, with different imaging protocols) instead of the native images.Our study is unique as it was designed specifically for radiologists. This study uses a dedicated, systematic scoring system from 2 experienced pediatric radiologists. The native images were all separately scored for the different types of abnormalities and were then compared. As our study happened at one investigation site, a more uniform scanning protocol was used.
: • Prospective• observational• performed at one institution
