Salinas-Miranda, Emmanuel
Deniffel, Dominik
Dong, Xin
Healy, Gerard M.
Khalvati, Farzad
O’Kane, Grainne M.
Knox, Jennifer
Bathe, Oliver F.
Baracos, Vickie E.
Gallinger, Steven
Haider, Masoom A. https://orcid.org/0000-0002-7165-8315
Funding for this research was provided by:
Ontario Institute for Cancer Research Translational Research Initiative in Pancreatic Cancer and Clinician Investigator Program
DFG (Deutsche Forschungsgemeinschaft) Fellowship DE (3207/1-1)
Clinical Research Scholarship from the Faculty of Radiologists, Royal College of Surgeons in Ireland
Article History
Received: 12 December 2020
Revised: 27 January 2021
Accepted: 16 March 2021
First Online: 2 May 2021
Declarations
:
: The scientific guarantor of this publication is Masoom A. Haider.
: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: The authors Xin Dong, who holds a master’s of science degree in mathematics, and Dr. Dominik Deniffel have significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: This retrospective, multicenter study was approved by our institutional review board and informed consent was obtained. Our study population was retrospectively selected from a prospective multi-institutional trial (COMPASS, NCT02750657) between December 2015 and April 2018.
: This cohort has been previously included in studies focusing on radiomics features in pre-chemotherapy CT scans and genomic profiling.ReferencesSalinas-Miranda E, Khalvati F, Namdar K, et al (2020) Validation of prognostic radiomic features from resectable pancreatic ductal adenocarcinoma in patients with advanced disease undergoing chemotherapy. <i>Can Assoc Radiol J</i>.O’Kane GM, Grünwald BT, Jang G-H, et al (2020) GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer<i>. Clin Cancer Res</i> 26:4901–4910.Aung KL, Fischer SE, Denroche RE, et al (2018) Genomics-driven precision medicine for advanced pancreatic cancer: early results from the COMPASS trial. <i>Clin Cancer Res</i> 24:1344–1354.
: • Retrospective• diagnostic or prognostic study• multicenter study