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Article History

Received: 20 October 2020

Revised: 11 March 2021

Accepted: 31 March 2021

First Online: 15 June 2021

Declarations

:

: The scientific guarantor of this publication is Prof. Dr. Marc Dewey

: The authors of this manuscript declare relationships with the following companies: Prof. Dr. Dewey has received grant support from the FP7 Program of the European Commission for the randomized multicenter DISCHARGE trial (603266-2, HEALTH-2012.2.4.-2). He also received grant support from German Research Foundation (DFG) in the Heisenberg Program (DE 1361/14-1), graduate program on quantitative biomedical imaging (BIOQIC, GRK 2260/1), for fractal analysis of myocardial perfusion (DE 1361/18-1), and the Priority Programme Radiomics for the investigation of coronary plaque and coronary flow (DE 1361/19-1 [428222922] and 20-1 [428223139] in SPP 2177/1). He also received funding from the Berlin University Alliance (GC_SC_PC 27) and from the Digital Health Accelerator of the Berlin Institute of Health. Prof. Dewey has received lecture fees from Canon, Guerbet. Prof. Dewey is European Society of Radiology (ESR) Research Chair (2019–2022) and the opinions expressed in this article are the author’s own and do not represent the view of ESR. Per the guiding principles of ESR, the work as Research Chair is on a voluntary basis and only remuneration of travel expenses occurs. Prof. Dewey is also the editor of <i>Cardiac CT</i>, published by Springer Nature, and offers hands-on courses on CT imaging (). Institutional master research agreements exist with Siemens, General Electric, Philips, and Canon. The terms of these arrangements are managed by the legal department of Charité–Universitätsmedizin Berlin. Professor Dewey holds a joint patent with Florian Michallek on dynamic perfusion analysis using fractal analysis (PCT/EP2016/071551). Other authors declared no conflicts of interest.

: One of the authors has significant statistical expertise.

: Written informed consent was waived by the Institutional Review Board.

: Institutional Review Board approval was obtained.

: • retrospective• randomized controlled trial• performed at one institution