Inglese, Francesca http://orcid.org/0000-0003-4569-4272
Kant, Ilse M. J.
Monahan, Rory C.
Steup-Beekman, Gerda M.
Huizinga, Tom W. J.
van Buchem, Mark A.
Magro-Checa, Cesar
Ronen, Itamar
de Bresser, Jeroen
Article History
Received: 17 November 2020
Revised: 16 March 2021
Accepted: 31 March 2021
First Online: 30 April 2021
Declarations
:
: The scientific guarantor of this publication is Dr. Jeroen de Bresser.
: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all patients in this study.
: Institutional Review Board approval was obtained. The Leiden-The Hague-Delft ethics approval committee approved the study.
: Some study subjects or cohorts have been previously reported. The Department of Rheumatology at the Leiden University Medical Center is a national referral center for neuropsychiatric systemic lupus erythematosus. Over the last 20 years, the Departments of Rheumatology and Radiology have been engaged in a research partnership, aiming at improving the diagnosis of NPSLE patients and increasing the usefulness of various conventional and quantitative MRI modalities in understanding disease mechanisms and improving patient classification. This collaboration resulted in more than 20 independent publications, many of them using imaging data originating from the same cohort. Although imaging data of the same cohort has been used in various studies in this collaborative effort, this current study is our first advanced quantitative structural analysis of this patient cohort, and we attest here that the data we report in this study has not been reported in any way or form in any of our previous publications.
: •Prospective•Cross-sectional study•Performed at one institution