Stocker, Daniel
Hectors, Stefanie
Bane, Octavia
Vietti-Violi, Naik
Said, Daniela
Kennedy, Paul
Cuevas, Jordan
Cunha, Guilherme M.
Sirlin, Claude B.
Fowler, Kathryn J.
Lewis, Sara
Taouli, Bachir http://orcid.org/0000-0001-6409-1333
Funding for this research was provided by:
National Cancer Institute (1U01CA172320)
Article History
Received: 27 February 2021
Revised: 22 April 2021
Accepted: 11 May 2021
First Online: 27 May 2021
Declarations
:
: The scientific guarantor of this publication is Bachir Taouli.
: The authors of this manuscript declare relationships with the following companies:Kathryn J. Fowler:Research grants: Bayer Healthcare, GE, PfizerConsulting: Epigenomics, 12 Sigma, Medscape, Bayer HealthcareClaude B. Sirlin:Industry research support: Bayer Healthcare, GE, Gilead, Philips, SiemensConsulting: EpigenomicsInstitutional Consulting Representative: IBM-WatsonBachir Taouli:Research grants: Bayer Healthcare, TakedaConsultant: Bayer Healthcare, AlexionAll other authors declare no conflict of interest.
: One of the authors (Stefanie Hectors) has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: Some participants (<i>n</i>=42) have been used in our previous studies on multiparametric MRI in HCC:1Bane O, Besa C, Wagner M et al (2016) Feasibility and reproducibility of BOLD and TOLD measurements in the liver with oxygen and carbogen gas challenge in healthy volunteers and patients with hepatocellular carcinoma. <i>J Magn Reson Imaging</i> 43:866–8762Hectors SJ, Wagner M, Bane O et al (2017) Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging. <i>Sci Rep</i> 7:24523Hectors SJ, Wagner M, Besa C et al (2016) Intravoxel incoherent motion diffusion-weighted imaging of hepatocellular carcinoma: is there a correlation with flow and perfusion metrics obtained with dynamic contrast-enhanced MRI? <i>J Magn Reson Imaging</i> 44:856–8644Jajamovich GH, Huang W, Besa C et al (2016) DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model versus shutter-speed model--initial experience. <i>MAGMA</i> 29:49–58
: • prospective• cross-sectional study• performed at one institution