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Article History

Received: 18 April 2022

Revised: 18 April 2022

Accepted: 30 May 2022

First Online: 2 July 2022

Declarations

:

: The scientific guarantor of this publication is Dr. Andreas Kammerlander

: Dr Kammerlander reports receiving a grant from the Austrian Society of Cardiology during the time of this work. Dr. Taron reports funding by Deutsche Forschungsgesellschaft (DFG, German Research Foundation) – TA 1438/1-2. T; speakers bureau Siemens Healthcare GmbH and speakers bureau Bayer AG, unrelated to this work. Dr Vasan is supported in part by the Evans Medical Foundation and the Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine. Dr Long is supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases K23 DK113252, the Doris Duke Charitable Foundation, Gilead Sciences Research Scholars Award, the Boston University School of Medicine Department of Medicine Career Investment Award, and the Boston University Clinical Translational Science Institute UL1 TR001430. Dr Long and is on the advisory board for Novo Nordisk and reports consulting fees for Iterative Scopes and Ionis Pharmaceuticals and research funding from Gilead Sciences and Echosens Corporation, all not related to the present research. Dr Hoffmann reports research support not related to the present research: research grants on behalf of the institution: KOWA, MedImmune, HeartFlow, Duke University, Oregon Health & Science University (American Heart Association, 13FTF16450001), Columbia University (National Institutes of Health [NIH], 5R01-HL109711), NIH/National Heart, Lung, and Blood Institute (NHLBI) 5K24HL113128, NIH/ NHLBI 5T32HL076136, NIH/NHLBI 5U01HL123339; and consulting fees: Duke University and Recor Medical.

: Dr. Lyass and Dr. Massaro kindly provided statistical advice for this manuscript.

: Written informed consent was obtained from all subjects (patients) in this study.

: Institutional Review Board approval was obtained.

: • prospective• observational• performed at one institution