Aapkes, Sophie E.
Barten, Thijs R. M.
Coudyzer, Walter
Drenth, Joost P. H.
Geijselaers, Ivo M. A.
ter Grote, Sterre A. M.
Gansevoort, Ron T.
Nevens, Frederik
van Gastel, Maatje D. A.
Article History
Received: 15 June 2022
Revised: 27 September 2022
Accepted: 29 November 2022
First Online: 14 January 2023
Declarations
:
: The scientific guarantor of this publication is Joost P.H. Drenth.
: The authors of this manuscript declare relationships with the following companies: Dr. Drenth has received grant support from Abbvie and Gilead. Dr. Gansevoort received grant support and fees for serving on advisory boards and steering committees from Galapagos, IPSEN, Otsuka Pharmaceuticals, and Sanofi-Genzyme. In addition, Dr. Gansevoort holds the Orphan Medicinal Product Designation status at the European Medicines Agency for lanreotide as treatment for kidney function decline in ADPKD (EMA/OD/027/15). All money is paid to their institutions. No other potential conflict of interest relevant to this article was reported.No grants have a relation with the current study.
: One of the authors (Maatje D.A. van Gastel) has significant statistical expertise regarding the analyses in our manuscript.
: Written informed consent was obtained from all UMC Groningen patients that participated in this study. These patients provided informed consent in previous studies and gave approval for use of their data for future studies.All Radboudumc patients are part of the international PLD registry. Written informed consent was waived by the Institutional Review Board for all data included in this database.
: Institutional Review Board approval was not required because this is a follow-up with data from previous studies for which Institutional Review is waived.
: Some study subjects or cohorts have been previously reported in Radboudumc and UMC Groningen studies with PLD patients. The current cohort however has not been reported earlier because patients could only be included if two axial CT scans, at least 6 months apart, were available.
: • cross-sectional study• multicenter study