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Article History

Received: 9 March 2022

Revised: 13 January 2023

Accepted: 22 February 2023

First Online: 11 May 2023

Declarations

:

: The scientific guarantor of this publication is Yihui Guan.

: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

: Yanyan Kong kindly provided statistical advice for this manuscript. One of the authors has significant statistical expertise. No complex statistical methods were necessary for this paper.

: Approval from the institutional animal care committee was obtained.

: Institutional review board approval was obtained. All animal studies were performed in accordance with the guidelines of the Animal Welfare Office of Fudan University. The Institutional Animal Care and Use Committee of Fudan University reviewed and approved the experimental procedures. The animals were maintained under anesthesia during the model development, injection, accumulation, and scanning periods to avoid suffering at each stage of the experiment.

: No study subjects or cohorts have been previously reported.

: • experimental study