Cheung, Wing Keung
Pakzad, Ashkan
Mogulkoc, Nesrin
Needleman, Sarah
Rangelov, Bojidar
Gudmundsson, Eyjolfur
Zhao, An
Abbas, Mariam
McLaverty, Davina
Asimakopoulos, Dimitrios
Chapman, Robert
Savas, Recep
Janes, Sam M.
Hu, Yipeng
Alexander, Daniel C.
Hurst, John R.
Jacob, Joseph http://orcid.org/0000-0002-8054-2293
Funding for this research was provided by:
Wellcome Trust (209553/Z/17/Z)
UCLH Biomedical Research Centre
Article History
Received: 10 October 2022
Revised: 17 April 2023
Accepted: 18 April 2023
First Online: 28 July 2023
Declarations
:
: The scientific guarantor of this publication is Dr Joseph Jacob.
: JJ reports fees from Boehringer Ingelheim, Roche, NHSX, Takeda, and GlaxoSmithKline unrelated to the submitted work. JJ was supported by Wellcome Trust Clinical Research Career Development Fellowship 209553/Z/17/Z and the NIHR Biomedical Research Centre at University College London. SMJ reports fees from AstraZeneca, Bard1 Bioscience, Achilles Therapeutics, and Jansen unrelated to the submitted work. SMJ received assistance for travel to meetings from AstraZeneca to American Thoracic Conference 2018 and from Takeda to World Conference Lung Cancer 2019 and is the Investigator Lead on grants from GRAIL Inc, GlaxoSmithKline plc, and Owlstone. WKC, AP, SN, BR, EG, AZ, MA, DM, DA, RC, RS, YH, DCA, NM, and JRH report no relevant conflicts of interest.
: One of the authors has significant statistical expertise.
: Written informed consent was waived by the Institutional Review Board.
: Approval for this retrospective study of clinically indicated pulmonary function and CT data was obtained from the local research ethics committees and Leeds East Research Ethics Committee: 20/YH/0120.
: Some study subjects or cohorts have been previously reported two manuscripts: ExternalRef removed and ExternalRef removed. These studies evaluated emphysema and an imaging pattern called pleuroparenchymal fibroelastosis respectively in a larger number of patients from the same cohort. Automated analyses of the airways were not performed in either study. IPF is a rare disease and therefore it is quite common for the same patients to be evaluated in different studies that use different analytic tools and (visual vs automated) scoring methodologies.
: • Retrospective• observational• performed at one institution