Herrera, Christina L.
Wang, Yiming
Udayakumar, Durga
Xi, Yin
Do, Quyen N.
Lewis, Matthew A.
Owen, David M.
Fei, Baowei
Spong, Catherine Y.
Twickler, Diane M.
Madhuranthakam, Ananth J.
Funding for this research was provided by:
National Institute of Child Health and Human Development (K23HD103876)
Article History
Received: 7 August 2022
Revised: 5 May 2023
Accepted: 17 May 2023
First Online: 19 July 2023
Declarations
:
: The scientific guarantor of this publication is Ananth Madhuranthakam, PhD.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors (Yin Xi) has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: None of the study subjects or cohorts has been previously reported in publications. However, the subjects reported in this study represent the preliminary evaluation in our ongoing large-scale study, where we plan to enroll 100 normal and 100 cHTN pregnancies for a total sample size of 200 subjects. This sample size was calculated to provide a minimal detectable effect size of 0.5 with 80% power at a significance level of 0.01 (performed with Bonferroni correction due to multiple measurements).
: • prospective• case–control study/observational study• performed at one institution