Mohamed, Mahmoud
Bosserdt, Maria
Wieske, Viktoria
Dubourg, Benjamin
Alkadhi, Hatem
Garcia, Mario J.
Leschka, Sebastian
Zimmermann, Elke
Shabestari, Abbas A.
Nørgaard, Bjarne L.
Meijs, Matthijs F. L.
Øvrehus, Kristian A.
Diederichsen, Axel C. P.
Knuuti, Juhani
Halvorsen, Bjørn A.
Mendoza-Rodriguez, Vladymir
Wan, Yung-Liang
Bettencourt, Nuno
Martuscelli, Eugenio
Buechel, Ronny R.
Mickley, Hans
Sun, Kai
Muraglia, Simone
Kaufmann, Philipp A.
Herzog, Bernhard A.
Tardif, Jean-Claude
Schütz, Georg M.
Laule, Michael
Newby, David E.
Achenbach, Stephan
Budoff, Matthew
Haase, Robert
Biavati, Federico
Mézquita, Aldo Vásquez
Schlattmann, Peter
Dewey, Marc http://orcid.org/0000-0002-4402-2733
,
Funding for this research was provided by:
Bundesministerium für Bildung und Forschung (01KG1110, 01KG1110)
Deutsche Forschungsgemeinschaft
Charité - Universitätsmedizin Berlin
Article History
Received: 6 March 2023
Revised: 29 June 2023
Accepted: 30 July 2023
First Online: 13 October 2023
Declarations
:
: The scientific guarantor of this publication is Marc Dewey.
: MB and VW report grant support from the FP7 Program of the European Commission for the randomized multicentre DISCHARGE trial (603266–2, HEALTH-2012.2.4.-2). BLN reports grants from Siemens and HeartFlow; JK received consultancy fees from GE Healthcare and AstraZeneca and speaker fees from GE Healthcare, Bayer, Lundbeck, Boehringer-Ingelheim, Pfizer and Merck, outside of the submitted work; RRB reports that the University Hospital Zurich holds a research agreement with GE Healthcare; PAK reports that the University Hospital Zurich holds a research agreement with GE Healthcare; GMS reports grants from the German Federal Ministry of Education and Research (BMBF), during the conduct of the study; DEN reports grants from Toshiba Medical Systems PS and MD had support from the joint programme of the German Research Foundation and the German Federal Ministry of Education and Research for the submitted work; PS has support from the German Research Foundation, grants from the European Union and grants from Bayer Pharma AG; MD has received grant support from the FP7 Program of the European Commission for the randomised multicentre DISCHARGE trial (603266–2, HEALTH-2012.2.4.-2). He also received grant support from German Research Foundation (DFG) in the Heisenberg Program (DE 1361/14–1), graduate program on quantitative biomedical imaging (BIOQIC, GRK 2260/1), for fractal analysis of myocardial perfusion (DE 1361/18–1), the Priority Programme Radiomics for the investigation of coronary plaque and coronary flow (DE 1361/19–1 [428222922] and 20–1 [428223139] in SPP 2177/1). He also received funding from the Berlin University Alliance (GC_SC_PC 27) and from the Digital Health Accelerator of the Berlin Institute of Health. MD has received lecture fees from Canon, Guerbet. MD is European Society of Radiology (ESR) Research Chair (2019–2022) and the opinions expressed in this article are the author’s own and do not represent the view of ESR. Per the guiding principles of ESR, the work as Research Chair is on a voluntary basis and only remuneration of travel expenses occurs. MD is also the editor of Cardiac CT, published by Springer Nature, and offers hands-on courses on CT imaging (ExternalRef removed). Institutional master research agreements exist with Siemens, General Electric, Philips, and Canon. The terms of these arrangements are managed by the legal department of Charité – Universitätsmedizin Berlin. MD holds a joint patent with Florian Michallek on dynamic perfusion analysis using fractal analysis (PCT/EP2016/071551); JCT reports grants from Amarin, AstraZeneca, Ceapro, DalCor Pharmaceuticals, Esperion, Ionis, Merck, Novartis, Pfizer and RegenXBio; honoraria from AstraZeneca, DalCor Pharmaceuticals, HLS Pharmaceuticals, Pendopharm and Pfizer; minor equity interest by DalCor Pharmaceuticals; and patents on pharmacogenomics-guided CETP inhibition and use of colchicine after myocardial infarction. PA H.A.: Institutional grants by Bayer, Canon, Guerbet, Siemens. H.A.: Speaker’s Bureau: Siemens. All other authors report no conflicts to exist.
: Two of the authors have significant statistical expertise.
: Written informed consent was obtained from all COME-CCT Consortium sites individually during the conduct of the original studies.
: All included original studies received approval from the local ethics committees to conduct their research. However, for this current sub-analysis, in which only anonymous data was analysed; hence, there was no need for additional ethical approval.
: This is a sub-analysis of the CoMe-CCT main cohort (5332 patients), published previously by Haase et al (2019), ExternalRef removed. Another sub-analysis of 2452 patients after the exclusion of 2880 patients (2878 patients without an available CAC score and 2 patients due to data inconsistency), Wieske et al (2022), ExternalRef removed.
: • prospective• diagnostic or prognostic study• multicentre study