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Authors
Harper, James G. https://orcid.org/0000-0003-3520-6060
York, Elizabeth N. https://orcid.org/0000-0002-4310-8607
Meijboom, Rozanna
Kampaite, Agniete
Thrippleton, Michael J.
Kearns, Patrick K. A.
Valdés Hernández, Maria del C.
Chandran, Siddharthan
Waldman, Adam D.
,
Akula, Amit
Baranzini, Sergio
Barret, Fiona
Bastin, Mark
Batchelor, Chris
Beswick, Emily
Brown, Fraser
Brunton, Tracy
Carod Artal, Javier
Chang, Jessie
Chen, Yingdi
Colville, Shuna
Connick, Peter
Cooper, Annette
Cranley, Denise
Dakin, Rachel
Dhillon, Baljean
Elliott, Liz
Finlayson, James
Foley, Peter
Glasmacher, Stella
Grossart, Angus
Haagenrud, Haane
Hafezi, Katarzyna
Harrison, Emily
Harroud, Adil
Hathorn, Sara
Hopkins, Tracey
Hunt, David
Hutchison, Aidan
Jardine, Charlotte
Jayprakash, Kiran
Justin, Matt
Kennedy, Gwen
Kessler, Lucy
Kleynhans, Michaela
Larraz, Juan
Love, Katherine
Lyle, Dawn
MacDonald, James
MacDougall, Niall
MacFarlane, Jen
Macfarlane, Lesley
Maclean, Alan
MacLennan, Bev
MacLeod, Margaret-Ann
Macleod, Nicola
Mahad, Don
Martin, Sarah-Jane
McCarthy, Conni
McMahon, Lynn
Mollison, Daisy
Megson, Ian
Mollison, Daisy
Monaghan, Mary
Murphy, Lee
Murray, Katy
Newton, Judith
Kwong, Julian Ng Kee
O’Riordan, Jonathan
Perry, David
Quigley, Suzanne
Scotson, Adam
Semple, Scott
Stenson, Amy
Stuart, Michaela
Weaver, Christine
Webb, Stuart
Weller, Belinda
White, Nicole
Williams, Anna
Wiseman, Stewart
Wong, Charis
Wong, Michael
Woodward, Rosie
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Funding
Funding for this research was provided by:
Chief Scientist Office, Scottish Government Health and Social Care Directorate (MMPP/01)
Anne Rowling Regenerative Neurology Clinic, Edinburgh
NHS Lothian Research and Development Office
Multiple Sclerosis Society (grant reference 133, grant reference 133)
Wellcome Trust (223058/Z/21/Z, 104916/Z/14/Z)
Scottish Funding Council
Precision Medicine Scotland Innovation Centre
Biogen Idec
Dunhill Medical Trust (R380R/1114)
Edinburgh and Lothians Health Foundation (2012/17)
Muir Maxwell Trust
Edinburgh Imaging
University of Edinburgh
UK Dementia Research Institute
Medical Research Council
Alzheimer's Society
Alzheimer’s Research UK
Mrs Gladys Row Fogo Charitable Trust (BRO-D.FID3668413)
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Article History
Received: 29 March 2023
Revised: 20 July 2023
Accepted: 29 August 2023
First Online: 9 November 2023
Declarations
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: The scientific guarantor of this publication is Professor Adam Waldman.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all subjects in this study.
: Institutional Review Board approval was obtained (South East Scotland Research Ethics Committee 02).
: The current article focuses on quantitative <i>T</i><sub><i>1</i></sub> data from a sub-cohort of FutureMS participants who received extended microstructural MRI, and test-retest healthy control <i>T</i><sub><i>1</i></sub> data, which have not been reported on previously.FutureMS studies which have been previously published:1. Glasmacher SA, Kearns PKA, Hassan Z, et al (2022) The influence of disease-modifying therapy on hidden disability burden in people with newly diagnosed relapsing-remitting multiple sclerosis. Multiple Sclerosis and Related Disorders. .2. Chang Y-T, Kearns PKA, Carson A, et al (2023) Network analysis characterizes key associations between subjective fatigue and specific depressive symptoms in early relapsing-remitting multiple sclerosis. Multiple Sclerosis and Related Disorders. .3. Kearns PKA, Martin SJ, Chang J, et al (2022) FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis. BMJ Open. .4. York EN, Meijboom R, Thrippleton MJ, et al (2022) Longitudinal microstructural MRI markers of demyelination and neurodegeneration in early relapsing-remitting multiple sclerosis: magnetisation transfer, water diffusion and g-ratio. Neuroimage: Clinical. .5. York EN, Martin SJ, Meijboom R, et al (2021) MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis. Brain Commun. .6. Ng Kee Kwong KC, Mollison D, Meijboom R, et al (2022) Rim lesions are demonstrated in early relapsing-remitting multiple sclerosis using 3 T-based susceptibility-weighted imaging in a multi-institutional setting. Neuroradiology. .7. Chen Y, Larraz J, Wong M, et al (2022) Longitudinal retinal imaging study of newly diagnosed relapsing-remitting multiple sclerosis in Scottish population: baseline and 12 months follow-up profile of FutureMS retinal imaging cohort. BMJ Open Ophthalmology. .8. Meijboom R, York EN, Kampaite A, et al Patterns of brain atrophy in recently-diagnosed relapsing-remitting multiple sclerosis. PLoS One. 2023;18(7):e0288967. Published 2023 Jul 28.
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