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Article History

Received: 6 June 2023

Revised: 23 August 2023

Accepted: 30 August 2023

First Online: 20 November 2023

Declarations

:

: The scientific guarantor of this publication is Philipp Latzin, MD PhD; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland. Mail: philipp.latzin@insel.ch

: Elisabeth Kieninger reports personal fees from Sanofi-Aventis outside the submitted work.Philipp Latzin reports personal fees from Gilead, Novartis, OM Pharma, Polyphor, Roche, Santhera, Schwabe, Vertex, Vifor, Zambon, and grants from Vertex, all outside the submitted work.All other authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

: No complex statistical methods were necessary for this paper.

: All parents or caregivers and patients ≥ 14 years gave informed written consent to participation in the study.

: Institutional Review Board approval was obtained: The study was approved by the Ethics Committee of Bern, Switzerland (ID 2017-00088).

: None of our study subjects or cohorts have been previously reported

: • retrospective• observational• performed at one institution