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Authors
van Voorst, Henk https://orcid.org/0000-0002-2647-3557
Pitkänen, Johanna
van Poppel, Laura
de Vries, Lucas
Mojtahedi, Mahsa
Martou, Laura
Emmer, Bart J.
Roos, Yvo B. W. E. M.
van Oostenbrugge, Robert
Postma, Alida A.
Marquering, Henk A.
Majoie, Charles B. L. M.
Curtze, Sami
Melkas, Susanna
Bentley, Paul
Caan, Matthan W. A.
,
Dippel, Diederik
Majoie, Charles
Majoie, Charles
van der Lugt, Aad
van Es, Adriaan
van Doormaal, Pieter-Jan
van den Berg, René
Beenen, Ludo
Emmer, Bart
Roosendaal, Stefan
van Zwam, Wim
Postma, Alida Annechien
Yo, Lonneke
Krietemeijer, Menno
Lycklama, Geert
Martens, Jasper
Hammer, Sebastiaan
Meijer, Anton
Bokkers, Reinoud
van der Hoorn, Anouk
van den Wijngaard, Ido
Yoo, Albert
Gerrits, Dick
van Oostenbrugge, Robert
Emmer, Bart
Coutinho, Jonathan M.
Truijman, Martine
Staals, Julie
van der Worp, Bart
Boogaarts, J.
Jansen, Ben
Zinkstok, Sanne
Roos, Yvo
Koudstaal, Peter
Dippel, Diederik
Coutinho, Jonathan M.
Keizer, Koos
Manschot, Sanne
Boiten, Jelis
Kerkhoff, Henk
van den Wijngaard, Ido
Lingsma, Hester
Dippel, Diederik
Chalos, Vicky
Berkhemer, Olvert
van der Lugt, Aad
Majoie, Charles
Versteeg, Adriaan
Wolff, Lennard
van der Sluijs, Matthijs
van Voorst, Henk
Tolhuisen, Manon
ten Cate, Hugo
de Maat, Moniek
Donse-Donkel, Samantha
van Beusekom, Heleen
Taha, Aladdin
Barakzie, Aarazo
Chalos, Vicky
van de Graaf, Rob
van der Steen, Wouter
Taha, Aladdin
Donse-Donkel, Samantha
Wolff, Lennard
Treurniet, Kilian
van den Berg, Sophie
LeCouffe, Natalie
Kappelhof, Manon
Reinink, Rik
Tolhuisen, Manon
Rinkel, Leon
Brouwer, Josje
Bruggeman, Agnetha
van Voorst, Henk
Goldhoorn, Robert-Jan
Hinsenveld, Wouter
Pirson, Anne
Olthuis, Susan
Venema, Simone Uniken
Teeselink, Sjan
Sondag, Lotte
Collette, Sabine
Sterrenberg, Martin
El Ghannouti, Naziha
van der Steen, Laurine
Verheesen, Sabrina
Vranken, Jeannique
van Ahee, Ayla
Bongenaar, Hester
Smallegange, Maylee
Tilet, Lida
de Meris, Joke
Simons, Michelle
Pellikaan, Wilma
van Wijngaarden, Wilma
Blauwendraat, Kitty
Drabbe, Yvonne
Sandiman-Lefeber, Michelle
Katthöfer, Anke
Ponjee, Eva
Eilander, Rieke
van Loon, Anja
Kraus, Karin
Kooij, Suze
Slotboom, Annemarie
de Jong, Marieke
van der Minne, Friedus
Santegoets, Esther
Heiligers, Leontien
Martens, Yvonne
El Ghannouti, Naziha
Roos, Yvo
Majoie, Charles
Treurniet, Kilian
Coutinho, Jonathan
Emmer, Bart
LeCouffe, Natalie
Kappelhof, Manon
Rinkel, Leon
Bruggeman, Agnetha
Roozenbeek, Bob
van Es, Adriaan
de Ridder, Inger
van Zwam, Wim
van der Worp, Bart
Lo, Rob
Keizer, Koos
Gons, Rob
Yo, Lonneke
Boiten, Jelis
van den Wijngaard, Ido
à Nijeholt, Geert Lycklama
Hofmeijer, Jeanette
Martens, Jasper
Schonewille, Wouter
Vos, Jan Albert
Tuladhar, Anil
Schreuder, Floris
Boogaarts, Jeroen
Jenniskens, Sjoerd
de Laat, Karlijn
van Dijk, Lukas
den Hertog, Heleen
van Hasselt, Boudewijn
Brouwers, Paul
Sturm, Emiel
Bulut, Tomas
Remmers, Michel
van Norden, Anouk
de Jong, Thijs
Rozeman, Anouk
Elgersma, Otto
Uyttenboogaart, Maarten
Bokkers, Reinoud
van Tuijl, Julia
Boukrab, Issam
Kortman, Hans
Costalat, Vincent
Arquizan, Caroline
Lemmens, Robin
Demeestere, Jelle
Desfontaines, Philippe
Brisbois, Denis
Clarençon, Frédéric
Samson, Yves
Roos, Yvo
Majoie, Charles
van Es, Adriaan
van Zwam, Wim
Boiten, Jelis
à Nijeholt, Geert Lycklama
Yo, Lonneke
Keizer, Koos
Coutinho, Jonathan
Emmer, Bart
Treurniet, Kilian
LeCouffe, Natalie
Kappelhof, Manon
Brown, Martin
White, Phil
Gregson, John
Nieboer, Daan
Dippel, Diederik
Majoie, Charles
Majoie, Charles
van der Lugt, Aad
van Zwam, Wim
Jacobi, Linda
van den Berg, René
Beenen, Ludo
Emmer, Bart
van Es, Adriaan
van Doormaal, Pieter-Jan
Lycklama, Geert
van den Wijngaard, Ido
Yoo, Albert
Yo, Lonneke
Martens, Jasper
Hammer, Bas
Roosendaal, Stefan
Meijer, Anton
Krietemeijer, Menno
Bokkers, Reinoud
van der Hoorn, Anouk
Gerrits, Dick
van Oostenbrugge, Robert
Emmer, Bart
Coutinho, Jonathan
Jansen, Ben
Roos, Yvo
Manschot, Sanne
Dippel, Diederik
Kerkhof, Henk
van den Wijngaard, Ido
Coutinho, Jonathan
Koudstaal, Peter
Keizer, Koos
Lingsma, Hester
Dippel, Diederik
Chalos, Vicky
Berkhemer, Olvert
van der Lugt, Aad
Majoie, Charles
Versteeg, Adriaan
Wolff, Lennard
Su, Jiahang
Tolhuisen, Manon
van Voorst, Henk
ten Cate, Hugo
de Maat, Moniek
Donse-Donkel, Samantha
van Beusekom, Heleen
Taha, Aladdin
Chalos, Vicky
Treurniet, Kilian
van den Berg, Sophie
LeCouffe, Natalie
van de Graaf, Rob
Goldhoorn, Robert-Jan
Taha, Aladdin
Donse-Donkel, Samantha
Hinsenveld, Wouter
Pirson, Anne
Sondag, Lotte
Kappelhof, Manon
Reinink, Rik
Tolhuisen, Manon
Brouwer, Josje
Wolff, Lennard
Collette, Sabine
van der Steen, Wouter
Sprengers, Rita
Sterrenberg, Martin
El Ghannouti, Naziha
Verheesen, Sabrina
Pellikaan, Wilma
Blauwendraat, Kitty
Drabbe, Yvonne
de Meris, Joke
Simons, Michelle
Bongenaar, Hester
van Loon, Anja
Ponjee, Eva
Eilander, Rieke
Kooij, Suze
de Jong, Marieke
Santegoets, Esther
Roodenburg, Suze
van Ahee, Ayla
Moynier, Marinette
Devroye, Annemie
Marcis, Evelyn
Iezzi, Ingrid
David, Annie
Talbi, Atika
Heiligers, Leontien
Martens, Yvonne
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Funding
Funding for this research was provided by:
Dutch Heart Foundation (CVON2015-01: CONTRAST)
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Article History
Received: 3 August 2023
Revised: 12 December 2023
Accepted: 16 December 2023
First Online: 29 January 2024
Declarations
:
: The scientific guarantor of this publication is Matthan W.A. Caan.
: The authors of this manuscript declare relationships with the following companies:Charles Majoie received funds from CVON/Dutch Heart Foundation and Stryker (related to this project, paid to institution) and from European Commission, Healthcare Evaluation Netherlands TWIN Foundation (unrelated to this project; all paid to institution) and is a shareholder of Nicolab. Bart Emmer received funds from Health Holland Top Sector Life Sciences, Nicolab, Healthcare Evaluation Netherlands (unrelated to this project; all paid to the institution). Henk Marquering is a co-founder and shareholder of Nicolab and TrianecT. Alinda Postma received an institutional grant from Siemens Healthineers and Bayer Healthcare. Matthan Caan received funds from Health~Holland Top Sector Life Sciences and Nicolab (unrelated to this project; all paid to the institution) and is a shareholder of Nicolab. Paul Bentley is funded by the National Institute for Health Research i4i Program II-LA-0814-20007 and the NIHR Imperial Biomedical Research Centre.The CONTRAST consortium acknowledges the support from the Netherlands Cardiovascular Research Initiative, an initiative of the Dutch Heart Foundation (CVON2015-01: CONTRAST), and from the Brain Foundation Netherlands (HA2015.01.06). The collaboration project is additionally financed by the Ministry of Economic Affairs by means of the PPP Allowance made available by the Top Sector Life Sciences & Health to stimulate public-private partnerships (LSHM17016). This work was funded in part through unrestricted funding by Stryker, Medtronic, and Cerenovus. The funding sources were not involved in study design, monitoring, data collection, statistical analyses, interpretation of results, or manuscript writing.Henk van Voorst is a member of the <i>European Radiology</i> Editorial Board. They have not taken part in the review or selection process of this article.
: One of the authors has significant statistical expertise: Henk van Voorst.
: Initial consent is received for the trial and subsequent use of all of the data was waived by an IRB.Data from collaborators at Imperial College London and Helsinki University Hospital was handled locally regarding ethical regulations. Deferred informed consent was received from patients included in the MR CLEAN No-IV trial for initial research and substudies after institutional review board approval.
: Data from collaborators at Imperial College London and Helsinki University Hospital was handled locally regarding ethical regulations. Deferred informed consent was received from patients included in the MR CLEAN No-IV trial for initial research and substudies after institutional review board approval.
: Some study subjects or cohorts have been previously reported:Patients included in this study were recruited from the MR CLEAN No-IV, a database from Imperial College London (IC), and a database from Helsinki University Hospital (HUH). In part, data from these databases have been published before:MR CLEAN NOIV trial DOI: Imperial college DIO: Helsinki University Hospital DOI: Reuse of dataThe IC data existed out of 118 previously published patients with CT that were used to train a machine learning model for Fazekas and WML volume estimation (1). We added 147 additional patients with CT and used deep-learning based segmentations to perform spatial and volumetric WML evaluation. The HUH data has partly been reported before for the spatial and volumetric evaluation of deep-learning based WML segmentation (2). We retrieved 101/147 HUH patients with CT to perform external validation of our model. We used 516 out of 539 patients from the MR CLEAN No-IV to perform a post hoc analysis of the risks of IVT before EVT based on WML burden (3). The MR CLEAN No-IV was a randomized controlled trial comparing IVT before EVT with EVT alone and did not study the effect of WML burden (3).
: • retrospective• diagnostic or prognostic study• multicenter study
