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Authors
Hamelink, Iris
van Tuinen, Marcel
Kwee, Thomas C.
van Ooijen, Peter M. A.
Vliegenthart, Rozemarijn https://orcid.org/0000-0002-7262-3376
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Funding
Funding for this research was provided by:
Siemens Healthineers
Ministerie van Economische Zaken
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Article History
Received: 27 May 2024
Revised: 31 October 2024
Accepted: 29 November 2024
First Online: 8 January 2025
Compliance with ethical standards
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: The scientific guarantor of this publication is Prof. Rozemarijn Vliegenthart.
: R.V. has received an institutional research grant and honorarium for lectures from Siemens Healthineers. The PhD project of Iris Hamelink is supported by a PUSH grant from Siemens Healthineers. The remaining authors have no disclosures to report.
: No complex statistical methods were necessary for this paper.
: Written informed consent was obtained from all subjects in this study.
: Institutional Review Board approval was obtained. The ImaLife study was registered with the Dutch Central Committee on Research Involving Human Subjects (, Identifier: NL58592.042.16).
: None of the prior ImaLife papers concerned vertebral or heart volume measurements. Prior papers on coronary calcium scoring were relating calcium scores to risk factors (PMID: 33525927, 33060489), compared manual calcium scoring on cardiac CT to chest CT acquisition in 1000 individuals (PMID: 32505593), and studied exclusion of coronary calcium based on an in-house AI model in 150 individuals (PMID: 32531719). Furthermore, we analyzed 240 participants with the same AI algorithm regarding aorta measurements, where we compared AI measurements to manual reading (PMID: 37659209).
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