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Authors
Creamer, Andrew W.
Horst, Carolyn
Verghese, Priyam
Prendecki, Ruth
Bhamani, Amyn
Hall, Helen
Dickson, Jennifer L.
Tisi, Sophie
Khaw, Chuen Ryan
McCabe, John
Gyertson, Kylie
Hacker, Anne-Marie
Farrelly, Laura
Hackshaw, Allan
Nair, Arjun
Devaraj, Anand
Janes, Sam M. https://orcid.org/0000-0002-6634-5939
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Janes, Sam M.
Dickson, Jennifer L.
Horst, Carolyn
Tisi, Sophie
Hall, Helen
Verghese, Priyam
Creamer, Andrew
Callender, Thomas
Prendecki, Ruth
Bhamani, Amyn
Ruparel, Mamta
Hackshaw, Allan
Farrelly, Laura
Teague, Jon
Mullin, Anne-Marie
Chan, Kitty
Sarpong, Rachael
Suresh, Malavika
Quaife, Samantha L.
Devaraj, Anand
Bowyer, Vicky
El-Emir, Ethaar
Airebamen, Judy
Cotton, Alice
Phua, Kaylene
Murali, Elodie
Mehta, Simranjit
Zylstra, Janine
Parry-Billings, Karen
Ife, Columbus
Neville, April
Robinson, Paul
Green, Laura
Hanif, Zahra
Kiconco, Helen
McEwen, Ricardo
Arancon, Dominique
Beech, Nicholas
Ovayolu, Derya
Hosein, Christine
Enes, Sylvia Patricia
Neville, Qin April
Rowlands, Jane
Samson, Aashna
Patel, Urja
Hoque, Fahmida
Pervez, Hina
Nnorom, Sofia
Miah, Moksud
McKee, Julian
Clark, Mark
Eng, Jeannie
Bojang, Fanta
Levermore, Claire
Patel, Anant
Lock, Sara
Banka, Rajesh
Bhowmik, Angshu
Ekeowa, Ugo
Mangera, Zaheer
Ricketts, William M.
Navani, Neal
O’Shaughnessy, Terry
Cash, Charlotte
Taylor, Magali
Hare, Samanjit
Aziz, Tunku
Ellis, Stephen
Edey, Anthony
Robinson, Graham
Villanueva, Alberto
Robbie, Hasti
Stefan, Elena
Sayer, Charlie
Screaton, Nick
Nundlall, Navinah
Gallagher, Lyndsey
Crossingham, Andrew
Buchan, Thea
Limani, Tanita
Gowers, Kate
Davies, Kate
McCabe, John
Jacob, Joseph
Sennett, Karen
Anastasiadis, Tania
Perugia, Andrew
Rusius, James
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Funding
Funding for this research was provided by:
Grail
Wellcome Trust (WT107963AIA)
Cancer Research UK (EDDCPGM\100002)
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Article History
Received: 18 November 2024
Revised: 6 March 2025
Accepted: 12 March 2025
First Online: 24 April 2025
Compliance with ethical standards
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: The scientific guarantor of this study is Prof Sam Janes.
: A.W.C., C.H., J.L.D., S.T., H.H., P.V., R.P., A.B. and R.K. are all funded or part-funded through GRAIL as part of the SUMMIT Study. SUMMIT is sponsored and conducted by University College London and funded by GRAIL LLC through a research grant awarded to S.M.J. as principal investigator. S.M.J.’s full disclosures are as a Paid Advisory Board member AstraZeneca, Bard1 Bioscience, Achilles Therapeutics, Jansen. Assistance for travel to meetings from AstraZeneca, Takeda, and grant income from GRAIL Inc, Owlstone and share options from Optellum; BARD1 Lifescience. N.N. is supported by a Medical Research Council Clinical Academic Research Partnership (MR/T02481X/1). N.N. reports honoraria for non-promotional educational talks or advisory boards from Amgen, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, EQRx, Fujifilm, Guardant Health, Intuitive, Janssen, Lilly, Merck Sharp & Dohme, Olympus and Roche. A.N. is part-funded through the UCLH Biomedical Research Centre. A.D.’s disclosures are personal fees from Boehringer Ingelheim, Roche, Galacto Biotech, Galapagos, Brainomix and Vicore. A.H.’s disclosures are consulting fees to Evidera and assistance for travel to meetings from GRAIL.
: Statistical input for the SUMMIT study was provided by Allan Hackshaw. No additional complex statistical methods were necessary for this analysis.
: Written consent was obtained from participants at the point of determining study eligibility.
: Ethical approval was obtained from an NHS Research Ethics Committee (17/LO/2004) and the NHS Health Research Authority’s Confidentiality Advisory Group (18/CAG/0054).
: All participants were part of the SUMMIT study; this is a large multi-faceted study which has generated a number of publications on a variety of aspects of lung cancer screening. This is the only paper looking at the question of newly-appearing nodules.
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