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Authors
Bane, Octavia https://orcid.org/0000-0003-1315-5848
Geahchan, Amine
Stocker, Daniel
Pavuluri, Swathi
Abboud, Ghadi
Kennedy, Paul
Sharma, Himanshu
Hectors, Stefanie J.
Thung, Swan
Jin, Ning
Fischman, Aaron
Markl, Michael
Reeder, Scott
Schiano, Thomas D.
Taouli, Bachir
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Funding
Funding for this research was provided by:
Division of Diabetes, Endocrinology, and Metabolic Diseases (5R01DK113272)
Sarnoff Cardiovascular Research Foundation
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Article History
Received: 16 October 2024
Revised: 19 May 2025
Accepted: 30 May 2025
First Online: 15 July 2025
Compliance with ethical standards
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: The scientific guarantor of this publication is Bachir Taouli.
: The authors of this manuscript declare relationships with the following companies: P.K. is an employee of Boston Scientific, and S.J.H. is an employee of Regeneron Pharmaceuticals, which are not sponsors of this project. N.J. is an employee of Siemens Healthineers, which supported this project with a prototype pulse sequence and data analysis software. B.T. received material support for this research from Siemens, in the form of a research 4D flow MRI pulse sequence and data analysis software. O.B., A.G., D.S., S.P., G.A., H.S., A.F., M.M., S.T., T.D.S. and S.R. declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: No complex statistical methods were necessary for this paper.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained from the Icahn School of Medicine at Mount Sinai Institutional Review Board.
: All patients in our cohort underwent multiparametric MRI (diffusion-weighted, DCE-MRI, T1, T1ρ, MR elastography and 4D flow). In the interest of clarity and brevity, we decided to present the data acquired with different MRI methods (e.g., 4D flow, T1 and T1ρ relaxometry, and elastography) separately. Some study subjects or cohorts have been previously reported in a published study on T1 and T1ρ mapping in portal hypertension (Hectors et al []), native and contrast-enhanced T1 (Altinmakas et al []), DCE-MRI (Hectors et al []) and MR elastography (Kennedy et al []). A subset of 10 patients was also included in a technical paper comparing two 4D flow methods (Bane et al []). We have presented preliminary results of this study in oral presentations at the annual meetings of the Society of Abdominal Radiology (2024, 2020), the Society of Advanced Body Imaging (2023), and the International Society of Magnetic Resonance in Medicine (2020).
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