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Article History

Received: 5 February 2025

Revised: 23 June 2025

Accepted: 7 July 2025

First Online: 21 October 2025

Compliance with ethical standards

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: The scientific guarantor of this publication is Myriam Margareta Keymling.

: The author Sebastian Bickelhaupt received lecture fees and project support from Siemens Healthineers unrelated to this work. D.M.R. is a junior deputy editor for European Radiology, and H.P.S. is a member of the Advisory Editorial Board of European Radiology (European Society of Oncologic Imaging). As such, these authors did not participate in the selection or review processes for this article. The remaining authors of this manuscript declare no relationships with any company, whose products or services may be related to the subject matter of the article.

: The author Thomas Hielscher has significant statistical expertise and provided advice on this matter.

: Written informed consent was obtained from all subjects in this study. Approval from the institutional animal care committee was not required because no animals were examined in this study.

: Institutional Review Board approval was obtained in both study locations (numbers: S-131/2020 and 9196_B0_K_2020).

: Of the 113 included participants, some were already reported in other articles: 47 participants were previously included in a study dealing with quality of life and fear of progression [], 49 in a paper examining health behavior in individuals with LFS [], and 61 in an analysis of genotype-phenotype associations in LFS []. None of the previous articles addresses imaging, while our manuscript deals with the optimization of a whole-body MRI protocol for cancer screening in individuals with LFS. There is no content overlap.

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