Document is current

Article History

Received: 9 February 2025

Revised: 19 July 2025

Accepted: 21 July 2025

First Online: 7 August 2025

Compliance with ethical standards

:

: The scientific guarantor of this publication is Shan-shan Lu.

: Yi-Cheng Hsu is an employee of Siemens. Shan-shan Lu is a guest editor for European Radiology and, as such, did not participate in the selection or review processes for this article. The remaining authors declare no conflicts of interest.

: Dr. Jin Liu from the clinical research institute, the first affiliated hospital of Nanjing Medical University, kindly provided statistical advice for this manuscript.

: Written informed consent was obtained from all patients in this study.

: Institutional Review Board approval was obtained.

: Sixty-three patients in this submission were included in our previous study (PMID: 39479945). However, the main purposes of these two studies are completely different. In the current study, we focus on the effect of different saturation powers (1, 1.5, and 2 μT) on CEST imaging in stroke patients. We identified an optimal saturation power (1 μT) for stroke imaging. In our previous study, we used the CEST parameters derived from NEMR metrics to characterize the tissue status after reperfusion therapy in patients with acute ischemic stroke and large vessel occlusion. We highlighted the potential of APT# values to complement perfusion and diffusion imaging in determining the effectiveness of reperfusion therapy and long-term clinical outcomes.

: