Nakagawara, Kensuke
Tanabe, Naoya
Chubachi, Shotaro https://orcid.org/0000-0002-5046-3762
Maetani, Tomoki
Shiraishi, Yusuke
Asakura, Takanori
Namkoong, Ho
Tanaka, Hiromu
Shimada, Takashi
Azekawa, Shuhei
Otake, Shiro
Fukushima, Takahiro
Watase, Mayuko
Terai, Hideki
Sasaki, Mamoru
Ueda, Soichiro
Kato, Yukari
Harada, Norihiro
Suzuki, Shoji
Yoshida, Shuichi
Tateno, Hiroki
Yamada, Yoshitake
Jinzaki, Masahiro
Hirai, Toyohiro
Okada, Yukinori
Koike, Ryuji
Ishii, Makoto
Kimura, Akinori
Imoto, Seiya
Miyano, Satoru
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
Funding for this research was provided by:
the Japan Agency for Medical Research and Development (JP20nk0101612)
the Japan Agency for Medical Research and Development (JP20fk0108415)
the Japan Agency for Medical Research and Development (JP21jk0210034)
the Japan Agency for Medical Research and Development (JP21km0405211)
the Japan Agency for Medical Research and Development (JP21km0405217)
the Japan Agency for Medical Research and Development (JP21wm0325031)
the Japan Agency for Medical Research and Development (JP20fk0108452)
the Japan Agency for Medical Research and Development (JP21fk0108563)
the Japan Agency for Medical Research and Development (JP21fk0108553)
the Japan Agency for Medical Research and Development (JP22wm0325031)
the Japan Agency for Medical Research and Development (JP21fk0108431)
the Japan Agency for Medical Research and Development (JP21fk0108510)
the Japan Agency for Medical Research and Development (JP22fk0108513)
the Japan Agency for Medical Research and Development (JP23tm0524008)
the Japan Agency for Medical Research and Development (JP21fk0108573)
the Japan Agency for Medical Research and Development (JP22fk0108537)
Core Research for Evolutional Science and Technology (JPMJCR20H2)
Precursory Research for Embryonic Science and Technology (JPMJPR21R7)
Ministry of Health, Labour and Welfare (20CA2054)
Article History
Received: 22 March 2025
Revised: 8 September 2025
Accepted: 3 October 2025
First Online: 24 December 2025
Compliance with ethical standards
:
: The scientific guarantor of this publication is Shotaro Chubachi.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written or oral informed consent was obtained from all participants.
: This study was approved by the Ethics Committee of the Keio University School of Medicine (ID: 20200061) and related research institutions. All the participants provided informed consent.
: No studies have been previously reported on the same subjects or cohorts.
: