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Article History

Received: 25 August 2025

Revised: 3 November 2025

Accepted: 15 November 2025

First Online: 19 February 2026

Compliance with ethical standards

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: The scientific guarantor of this publication is Prof. Shonit Punwani.

: The authors of this manuscript declare relationships with the following companies: F.G. reports consulting fees from SpectraCure and Procept outside of the submitted work. He has received speaker fees from Bayer and Siemens, is a member of the Scientific Editorial Board of European Radiology (section: Urogential), and the Guest Editor of the Active Surveillance of Prostate Cancer: MRI and beyond Collection; as such, he has not participated in the selection or review processes for this article. S.P. reports consulting fees from NVISION IMAGING, Gold Standard Phantoms and Quibim outside of the submitted work.

: One of the authors (T.P.) has significant statistical expertise.

: Written informed consent was obtained from all subjects (patients) in the original IP1-PROSTAGRAM study. The original study consent form included a specific optional clause allowing the use of data for future retrospective research. The current study only includes participants who provided this consent.

: Institutional Review Board approval was obtained for the original IP1-PROSTAGRAM study. Ethical approval was granted by the UK National Research Ethics Committee (reference: 8/LO/1338).

: Participants from IP1-PROSTAGRAM have been included in prior publications: Eldred-Evans et al [ ], Eldred-Evans et al [ ], and Day et al [ ].

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