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Authors
Riedel, Evamaria O. https://orcid.org/0000-0003-2259-9221
Schramm, Severin
Bongratz, Fabian
Gruber, Martin J.
Sepp, Dominik
Paprottka, Karolin J.
Zimmer, Claus
Wiestler, Benedikt
Hedderich, Dennis M.
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Funding
Funding for this research was provided by:
Faculty of Medicine, Munich University of Technology (TUM KKF Clinician Scientist Program, project reference E-19 and H-27)
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Article History
Received: 20 May 2025
Revised: 14 November 2025
Accepted: 18 December 2025
First Online: 27 February 2026
Compliance with ethical standards
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: The scientific guarantor of this publication is Dennis M. Hedderich.
: B. Wiestler has disclosed no relevant relationships pertaining to activities associated with this article but has received speaker honoraria from Philips. C. Zimmer has disclosed no relevant relationships concerning this article but has served on scientific advisory boards for Philips and Bayer Schering. C. Zimmer is also a co-editor on the Advisory Board of Clinical Neuroradiology and has received speaker honoraria from Bayer-Schering and Philips. Additionally, C. Zimmer's institution has received research support and investigator fees for clinical studies from multiple companies, including Biogen Idec, Quintiles, MSD Sharp & Dohme, and Boehringer Ingelheim. D.M. Hedderich is Section Editor for Advanced Imaging of Neuroradiology and has received speakers’ honoraria from Eisai GmbH. All other authors declare no conflicts of interest.
: No complex statistical methods exceeding the statistical expertise of the authors were necessary for this paper.
: Written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained (2024-71-S-CB).
: The patients of the cohort used here were all part of a larger cohort in: Hedderich et al, normative brain volume reports may improve differential diagnosis of dementing neurodegenerative diseases in clinical practice, European Radiology , 2020 and to a small part in Hedderich et al, Impact of normative brain volume reports on the diagnosis of neurodegenerative dementia disorders in neuroradiology: a real-world, clinical practice study, Frontiers in Aging Neuroscience, 2022. The current study investigates the preservation of atrophy patterns in neurodegenerative diseases and the impact on automated disease classification, and therefore has a completely different research focus than the other two studies, which investigated the effect of Normative brain volume reports on the diagnosis made by human radiologists.
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