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Authors
Nakanishi, Rine
Okubo, Ryo
Matsuo, Hitoshi
Sobue, Yoshihiro
Kaneko, Umihiko
Sato, Hideyuki
Fujimoto, Shinichiro
Nozaki, Yui
Kajiya, Takashi
Miyoshi, Toru
Ichikawa, Keishi
Abe, Mitsunori
Kitagawa, Toshiro
Ikenaga, Hiroki
Osawa, Kazuhiro
Saji, Mike
Iguchi, Nobuo
Nakazawa, Gaku
Takahashi, Kuniaki
Ijichi, Takeshi
Mikamo, Hiroshi
Kurata, Akira
Moroi, Masao
Iijima, Raisuke
Bandeira, Daniel
Demuyakor, Abigail
Parise, Helen
Malkasian, Shant
Mintz, Gary S.
Lansky, Alexandra J.
Earls, James P.
Chamié, Daniel https://orcid.org/0000-0003-3258-2458
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Funding
Funding for this research was provided by:
Cleerly Inc.
Japan Society for the Promotion of Science (22K08216)
NIH T32 Clinician-Scientist Training Program (EB005970)
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Article History
Received: 24 September 2025
Revised: 2 February 2026
Accepted: 3 February 2026
First Online: 5 March 2026
Compliance with ethical standards
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: The scientific guarantor of this publication is Daniel Chamie, MD, PhD.
: The authors of this manuscript declare relationships with the following companies: Rine Nakanishi: None. Ryo Okubo: None. Hitoshi Matsuo: Speakers’ bureau of Abbott Vascular, Philips, HeartFlow, Amgen, and Zeon Medical. Yoshihiro Sobue: None. Umihiko Kaneko: None. Hideyuki Sato: None. Shinichiro Fujimoto: None. Yui Nozaki: None. Takashi Kajiya: None. Toru Miyoshi: None. Keishi Ichikawa: None. Mitsunori Abe: None. Toshiro Kitagawa: None. Hiroki Ikenaga: None. Kazuhiro Osawa: None. Mike Saji: None. Nobuo Iguchi: None. Gaku Nakazawa: Speaker fees from Boston Scientific, Abbott Medical, Terumo Corp, and HeartFlow Japan. Kuniaki Takahashi: None. Takeshi Ijichi: Speakers’ bureau—Novartis Pharma, AstraZeneca, and Bayer Pharma. Hiroshi Mikamo: None. Akira Kurata: Member of the Scientific Editorial Board of European Radiology and, as such, did not participate in the selection or review processes for this article. Masao Moroi: None. Raisuke Iijima: None. Daniel Bandeira: None. Abigail Demuyakor: None. Helen Parise: None. Shant Malkasian: Consultant for and equity interest in Cleerly Inc. Gary S. Mintz: Honoraria—Boston Scientific. Alexandra J. Lansky: None. James P. Earls: Consultant for and equity interest in Cleerly Inc. Daniel Chamié: Consulting and speaker fees from Boston Scientific.
: Statistical analysis of the current work was performed at Yale University, under the leadership of Helen Parise, ScD, who is a co-author of this manuscript.
: All prospective patients provided written informed consent. For retrospective cases, opt-out forms were posted on each facility’s website and/or local sites to inform patients who did not wish their information included in the study.
: The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the Ethics Committee of Toho University Omori Medical Center (M24009_22063_21054_19012). It was prospectively registered at ClinicalTrials.gov (NCT04066062).
: None of the study subjects or cohorts has been previously reported.
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