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Article History

Received: 20 March 2026

Revised: 22 May 2026

Accepted: 20 June 2026

First Online: 22 July 2026

Compliance with ethical standards

Guarantor: The scientific guarantor of this publication is Akos Varga-Szemes.

Conflict of interest: Dr. Vecsey-Nagy is a consultant for Elucid Bioimaging and receives travel support and speaker fees from Siemens Healthineers. Gülsün and Sharma are employees of Siemens Healthineers. Siemens Healthineers had no role in study design, data acquisition, data analysis, data interpretation, or manuscript preparation, and the academic authors, not employed by the company, had full control over all data and information submitted for publication. Dr. Szilveszter and Dr. Maurovich-Horvat receive institutional research and travel support from Siemens Healthineers. Dr. Varga-Szemes receives institutional research and travel support from Siemens Healthineers and Bayer Healthcare and is a consultant and shareholder for Elucid Bioimaging. Dr. Emrich is a consultant for Circle Cardiovascular Imaging Inc. and receives travel support, speaker fee and institutional research support from Siemens Healthineers.

Statistics and biometry: One of the authors has statistical expertise. No complex statistical methods were necessary for this paper.

Informed consent: Written consent was obtained from all patients in this study.

Ethical approval: Institutional Review Board approval was obtained (Pro00108359).

Study subjects or cohorts overlap: This study draws from the same intra-individual cohort as a previous Radiology publication (10.1148/radiol.241479), but it addresses a distinctly different scientific rationale and purpose. Whereas the earlier work characterized scanner-related differences using reconstruction settings optimized for UHR, the present analysis focuses on harmonizing reconstruction settings between detector technologies, maximizing reproducibility, and providing a practical framework for trial planning using a novel automated plaque quantification tool. We confirm that this manuscript is original, has not been published previously, and is not under review elsewhere.

Methodology: