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Article History

Received: 23 October 2019

Accepted: 25 March 2020

First Online: 19 April 2020

Compliance with ethical standards

:

: The authors declare that they have no competing interests.

: The datasets generated and analyzed during the current study are not publicly available as the experimental data are related to other experiments that are progressing, but are available from the corresponding author on reasonable request.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Shandong Provincial Third Hospital Medical Ethics Committee (KYLL-2018003) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. All animal experiments complied with the ARRIVE guidelines, were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH publications no. 8023, revised 1978) and were approved by the Ethics Committee on the Care and Use of Laboratory Animals (approval no. 2019076), Qilu Hospital, Shandong University, Jinan, P. R. China.

: Informed consent was obtained from all individual participants included in the study.