Paasche, Amelie
Wiedmann, Felix
Kraft, Manuel
Seibertz, Fitzwilliam
Herlt, Valerie
Blochberger, Pablo L.
Jávorszky, Natasa
Beck, Moritz
Weirauch, Leo
Seeger, Timon
Blank, Antje
Haefeli, Walter E.
Arif, Rawa
Meyer, Anna L.
Warnecke, Gregor
Karck, Matthias
Voigt, Niels
Frey, Norbert
Schmidt, Constanze http://orcid.org/0000-0001-5897-237X
Funding for this research was provided by:
Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung. (Clinician Scientist Program)
Deutsche Stiftung für Herzforschung (F/03/19)
Deutsche Forschungsgemeinschaft (SCHM 3358/1-1, VO 1568/3-1, VO 1568/4-1)
Else Kröner-Fresenius-Stiftung (Clinician Scientist Professorship)
Universitätsklinikum Heidelberg
Article History
Received: 7 May 2023
Revised: 8 November 2023
Accepted: 24 November 2023
First Online: 3 January 2024
Declarations
:
: C.S. received research funding from Böhringer Ingelheim, Ingelheim, Germany. All other authors declare that they have no competing interests.
: The study protocol involving human tissue samples was approved by the responsible Ethics Committee of the Medical Faculty of Heidelberg University (Germany; S-017/2013) and was conducted in accordance with the 1964 Declaration of Helsinki. Human induced pluripotent stem cell (hiPSC) line UMGi014-C clone 14 (isWT1.14) was derived from dermal fibroblasts of a healthy male donor and experimental protocols were approved by the ethics committee of the University Medical Center Göttingen (10/9/15). All animal experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals adopted by the US National Institutes of Health (NIH publication No. 86–23, revised 1985), with EU Directive 2010/63/EU, with the current version of the German Law on the Protection of Animals, and the ARRIVE guidelines. The study protocol was approved by the local Animal Welfare Committee (Regierungspräsidium Karlsruhe, Germany, reference numbers G-165/19; G-67/20; G-229/21).
: Written informed consent was obtained from all individual participants included in the study.