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Authors
Wang, Hong https://orcid.org/0000-0001-5700-6786
Paavola, Jere
Perttunen, Sanni
Immonen, Katariina
Hägerström, Ian
Narumanchi, Suneeta
Kalervo, Karri
Tolva, Johanna
Sinisalo, Juha
Mäyränpää, Mikko I.
Ruskoaho, Heikki
Kosonen, Riikka
Olkkonen, Vesa M.
Laine, Mika
Tikkanen, Ilkka
Lakkisto, Päivi
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Funding
Funding for this research was provided by:
Suomen Kulttuurirahasto
Sydäntutkimussäätiö
Aarne Koskelon Säätiö
the Finnish Foundation for Laboratory Medicine
Finska Läkaresällskapet
Medicinska Understödsföreningen Liv och Hälsa
Sigrid Juséliuksen Säätiö
Finnish state funding for university-level research
University of Helsinki
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Article History
Received: 8 January 2026
Revised: 18 June 2026
Accepted: 5 July 2026
First Online: 3 August 2026
Declarations
Conflict of interest: The authors declare that there is no conflict of interest associated with this manuscript.
Ethical approval: Zebrafish experiments were approved by the Regional State Administrative Agency for Southern Finland in agreement with the ethical guidelines of the European convention (ESAVI/2988/04.https://doi.org/10.07/2014; ESAVI/4131/04. https://doi.org/10.07/2017 ; ESAVI/16286/2020).The investigation of human samples was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of Helsinki and Uusimaa Hospital District, Finland. Written informed consent was obtained from all patients. The National Authority for Medicolegal Affairs approved the usage of tissues from organ donors.
