Lacampagne, Alain
Liu, Xiaoping
Reiken, Steven
Bussiere, Renaud
Meli, Albano C.
Lauritzen, Inger
Teich, Andrew F.
Zalk, Ran
Saint, Nathalie
Arancio, Ottavio
Bauer, Charlotte
Duprat, Fabrice
Briggs, Clark A.
Chakroborty, Shreaya
Stutzmann, Grace E.
Shelanski, Michael L.
Checler, Frederic
Chami, Mounia http://orcid.org/0000-0003-1498-7187
Marks, Andrew R.
Funding for this research was provided by:
National Heart, Lung, and Blood Institute (R01HL061503)
National Heart, Lung, and Blood Institute (R01HL102040)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS-R01AR060037)
National Institute of Mental Health (NIH T32 HL120826)
National Institute of Neurological Disorders and Stroke (R25NS076445)
the Fondation Leducq and a generous donation from Carol Stix
LABEX (excellence laboratory, program investment for the future) DISTALZ
the University Hospital Federation (FHU) OncoAge
Fondation Pompidou
LECMA (13737)
Niagara University (RO1AG030205)
Schaefer Award from Columbia University
Article History
Received: 2 February 2017
Revised: 24 May 2017
Accepted: 27 May 2017
First Online: 19 June 2017
Compliance with ethical standards
:
: All applicable international, national and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.In vivo experiments were performed in accordance with the regulations of the Institutional Animal Care and Use Committee of Columbia University (APP<sup>+/−</sup>/PS1<sup>+/−</sup>, <i>RyR2</i>-<i>S2808A</i><sup>+<i>/</i>+</sup><i>, and RyR2</i>-<i>S2808D</i><sup>+<i>/</i>+</sup><i>mice</i>) and with the guidelines established by the European Community Council (Directive of November 24th, 1986) and approved by the Nice University Animal care and use Committee and the National Council on animal care of the Ministry of Health (Project No: NCE/2013-152) (3 × Tg-AD mice).All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical studies.
: Informed consent for tissue donation for research was obtained by the brain banks under their approval procedures.
: ARM is a board member and owns shares in ARMGO Pharma Inc., which is targeting RyR channels for therapeutic purposes.