VandeVrede, Lawren http://orcid.org/0000-0002-8304-6711
La Joie, Renaud
Horiki, Sheena
Mundada, Nidhi S.
Koestler, Mary
Hwang, Ji-Hye
Ljubenkov, Peter A.
Rojas, Julio C.
Rabinovici, Gil D.
Boxer, Adam L.
Seeley, William W.
Funding for this research was provided by:
National Institute on Aging (K23AG073514)
Alzheimer's Association
Article History
Received: 14 June 2023
Revised: 5 September 2023
Accepted: 6 September 2023
First Online: 19 September 2023
Declarations
:
: LV has served as site principle investigator for Biogen-sponsored clinical trials and receives research support from the Alzheimer’s Association. PAL reported grants from the Alzheimer’s Association Part the Cloud program; serving as principal investigator for trials sponsored by Woolsey Pharmaceuticals, Transposon, Alector, and AbbVie. JCR reports serving as site principle investigator for Biogen-sponsored clinical trials. GDR receives research support from Avid Radiopharmaceuticals, GE Healthcare, Life Molecular Imaging, Genentech. In the past 3 years, he has received consulting fees from Alector, Eli Lilly, GE Healthcare, Johnson & Johnson, Genentech, Roche, and Merck. ALB reported grants from Rainwater Charitable Foundation during the conduct of the study and stocks/options from Alector, Arvinas, Arkuda, Truebinding, and AZTherapies; personal fees from the AIDS Clinical Trials Group, Boehringer Ingelheim, GSK, Denali Therapeutics, Oligomerix, Merck, Roche, Transposon, Wave, Oscotec, and Alzprotect; and grants from Biogen, Eisai, Regeneron, Bluefield Project, the Alzheimer’s Association, and CurePSP.
: Autopsy authorization, consent to utilize tissues for research, and consent to publish was obtained according to approved protocols of the UCSF Neurodegenerative Brain Bank. The research study was approved by the UCSF Alzheimer Disease Research Center (ADRC). The UCSF, University of California Berkeley, and Lawrence Berkeley National Laboratory institutional review boards (IRB) approved the tau PET studies. IRB approval and patient consent for ENGAGE was obtained at UCSF. Clinical trial data were collected through ENGAGE, and Biogen reviewed and commented on the manuscript prior to submission but did not have editorial authority. Biogen incorporated and funded the ENGAGE trial, but did not provide direct funding to the authors and were not involved in data analysis or interpretation. The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.