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Preservation of miR-9-5p and miR-124-3p in ALS-resistant oculomotor neurons contrasts with their downregulation in vulnerable spinal motor neurons, irrespective of TDP-43 pathology

Crossref DOI link: https://doi.org/10.1007/s00401-026-03005-6

Published Online: 2026-03-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

McLellan, Crystal

Campos-Melo, Danae

Hammond, Robert

Strong, Michael J.
Funding

Funding for this research was provided by:

Canadian Institutes of Health Research (201806SOP-411481)
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Text and Data Mining valid from 2026-03-26

Version of Record valid from 2026-03-26
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Article History

Received: 4 September 2025

Revised: 19 March 2026

Accepted: 20 March 2026

First Online: 26 March 2026

Declarations

:

: The authors declare that there are no competing interests.

: Ethics approval for the use of human postmortem tissue was obtained from the University of Western Ontario, Health Sciences Research Ethics Board (HSREB) (protocols #103735 and #124855).

: Informed consent for autopsy and retention of tissues for research purposes was obtained in written format from all patients antemortem or, if not possible, from their spouses postmortem. No minors participated in this study. To ensure anonymization, at the time of utilization for this research project, all cases were assigned a unique identifier with the master list correlating the unique identifiers maintained in a locked cabinet in the office of the principal investigator (MJS) as per HSREB requirements.

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