Funding for this research was provided by:
National Natural Science Foundation of China (81200607)
Guangzhou Medical University (2017B11)
Article History
Received: 30 September 2021
Accepted: 3 July 2022
First Online: 13 July 2022
Declarations
:
: The authors have no conflicts of interest to declare that are relevant to the content of this article.
: All the procedures performed in this clinical trial were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. On January 8th, 2016, the study was approved by the Medical Ethics Committee of The Third Affiliated Hospital of Guangzhou Medical University (Approved ethic committee number: 002/2016). The study was registered at Chinese Clinical Trials Registry (ChiCTR-IIR-16008084) on 13/3/2016. The long-term follow-up procedures of this clinical trial was reapproved by the Medical Ethics Committee of The Third Affiliated Hospital of Guangzhou Medical University (Approved ethic committee number: 061/2018) on July 18th, 2018. The study was reregistered at Chinese Clinical Trials Registry (ChiCTR1900020516).
: Informed consent was obtained from all individual participants included in the study.