Hoshino, Makoto https://orcid.org/0009-0003-6637-8030
Sakata, Kiyohiko https://orcid.org/0000-0003-2019-1732
Kajiwara, Sosho https://orcid.org/0000-0001-5847-4573
Mihashi, Ryota
Ohkubo, Taku
Hashimoto, Aya
Otsu, Yusuke https://orcid.org/0000-0002-7578-4247
Ono, Takeharu https://orcid.org/0000-0003-2414-7034
Umeno, Hirohito https://orcid.org/0000-0002-2347-495X
Morioka, Motohiro https://orcid.org/0000-0001-7179-1258
Article History
Received: 14 October 2025
Accepted: 1 December 2025
First Online: 12 January 2026
Declarations
:
: This study including two cases report was approved by the Regional Ethics Committee of the Faculty of Medicine, Kurume University Hospital (2022-070) and was performed in accordance with the guidelines of the Declaration of Helsinki. This systematic review is based on data that has already been published and is not registered as a clinical trial.
: Both patients provided written informed consent to participate in this study and agreed to the proposed treatment plan after all options for the management of petrous apex cholesterol granuloma were clearly explained.
: All authors have read and approved the final manuscript. Both patients described in this study approved the publication of this study.
: not applicable.
: The authors have no competing interests to declare that are relevant to the content of this article.