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Article History

Received: 26 July 2021

Accepted: 8 November 2021

First Online: 25 November 2021

Declarations

:

: All authors report no financial relationships with commercial interests related to this article. Beyond that, CB receives honoraria as a diagnostic consultant for Boehringer Ingelheim and received honoria for lectures from Roche. CB, PH, MAH, KR, and MB receive funding from the German Alzheimer Association. US is consultant for Boehringer Ingelheim, Germany. BHS holds grants from the German Research Foundation (DFG), as well as the European Union and the State of Saxony-Anhalt (Research Alliance “Autonomy in Old Age”). JW is supported by an Ilídio Pinho professorship, iBiMED (UIDB/04501/2020) at the University of Aveiro, Portugal. JW is an advisory board member of Abbott, Biogen, Boehringer Ingelheim, Immunogenetics, Lilly, MSD Sharp & Dohme, and Roche Pharma. JW received honoraria for lectures from the AGNP, Actelion, Amgen, Beeijing Yibai Science and Technology Ltd., CSF-Society, Helios Klinikum Wuppertal, Janssen Cilag, Med Update GmbH, Pfizer, Roche Pharma, Vitos Kurhessen-Bad Emstal, as well as funding from the German Federal Ministry for Education and Research (BMBF), the European Union (EU), and the German Research Foundation (DFG). JW holds the following patents: PCT/EP 2011 001724 and PCT/EP 2015 052945. CWM advises Janssen Cilag and LivaNova on an honorary basis. He advises the following hospitals and the hospital company: Amelung Klinik, hospital company: Mecklenburg-Vorpommern, Berlin-Brandenburg, Niedersachsen. CWM completes seminars for: mibeg institutes, PKM.

: The study complies with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. All procedures involving human subjects/patients were approved by the of the ethics committee of the University Medical Center Goettingen, Germany (#36/4/20).

: Please see section “study sample” for details.