Document is current
Any future updates will be listed below
-
Authors
Morgado, Barbara https://orcid.org/0000-0001-8174-9301
Klafki, Hans-Wolfgang https://orcid.org/0000-0002-8672-9032
Bauer, Chris https://orcid.org/0000-0002-4199-5468
Steiert, Annik https://orcid.org/0009-0005-4502-1344
Waniek, Katharina https://orcid.org/0000-0002-2925-5790
Lachmann, Ingolf https://orcid.org/0000-0002-9225-1493
Osterloh, Dirk https://orcid.org/0009-0002-8832-3164
Esselmann, Hermann https://orcid.org/0000-0001-5484-9710
Hansen, Niels https://orcid.org/0000-0001-5785-9594
Schuchhardt, Johannes https://orcid.org/0009-0008-8896-4328
Wiltfang, Jens https://orcid.org/0000-0003-1492-5330
-
Funding
Funding for this research was provided by:
Herzzentrum Göttingen
- License Information
-
More Information
Article History
Received: 2 December 2024
Accepted: 14 September 2025
First Online: 27 September 2025
Declarations
:
: JW has been an honorary speaker for Actelion, Amgen, Beeijing Yibai Science and Technology Ltd., Janssen Cilag, Med Update GmbH, Pfizer, Roche Pharma, and has been a member of the advisory boards of Abbott, Biogen, Boehringer Ingelheim, Lilly, MSD Sharp & Dohme, and Roche Pharma and receives fees as a consultant for Immungenetics and Roboscreen. JW holds the following patents: PCT/EP 2011 001724 and PCT/EP 2015 052945. CB and JS are employees of Microdiscovery GmbH, Berlin, Germany. IL, KW and DO are employees of Roboscreen GmbH, Leipzig, Germany.The scientists at Roboscreen were responsible for the development of an automated processing of the IP for Abeta and Tau as well as for the development of a Tau IP from blood plasma samples. BM, HWK, HE, OW and NH declare no competing interests.
: The collection and archiving of biological samples and clinical data in strictly pseudonymous form in a local biobank and their use in biomarker research were approved by the ethics committee of the University Goettingen (9/2/16). From all participants or their legal representatives written informed consent was obtained prior to the inclusion in the biobank. In detail, before inclusion in the study and removal of biomaterial, all study participants received detailed information and an information leaflet from the study physicians at the Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, before signing a written informed consent form. All study participants had MCI or mild dementia, so that they were able to give informed consent. If the ability to consent was not given, a separate informed consent form was also provided for the study participant's legal representative, and the legal representative signed the informed consent form for the study.All procedures involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: Not applicable.
