Funding for this research was provided by:
Ministerio de Ciencia e Innovación (SAF2006-10126, SAF2010-22329-C02-01)
Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Madrid, Spain (RETICS RD16/0006/0004, PI15/00303)
Junta de Extremadura, Mérida, Spain (GR18145, IB16170)
Text and Data Mining valid from 2018-11-27
Received: 18 September 2018
Revised: 19 November 2018
Accepted: 20 November 2018
First Online: 27 November 2018
Compliance with ethical standards
: All authors declare that they have no conflicts of interests.
: The study was approved by the corresponding ethics committees of the hospitals involved. Specifically, the Ethic Committees of Clinical Investigation of the Clínica Universitaria de Navarra (Pamplona, Spain), the Hospital Universitari Mutua de Terrassa (Terrassa, Barcelona, Spain), and the Infanta Cristina University Hospital (Badajoz, Spain). Written informed consent was obtained from all the participants before study enrollment.
: All data related to the current study, intended for reasonable use, is available from J.A.G. Agúndez (University Institute of Molecular Pathology Biomarkers, University of Extremadura -UNEx ARADyAL Instituto de Salud Carlos III, Av/ de la Universidad S/N, E10071 Cáceres. Spain) and F.J. Jiménez-Jiménez (Section of Neurology, Hospital del Sureste, Arganda del Rey, Madrid, Spain).