Funding for this research was provided by:
Text and Data Mining valid from 2019-02-18
Received: 29 October 2018
Revised: 6 February 2019
Accepted: 7 February 2019
First Online: 18 February 2019
Conflicts of interest
: This project was funded by Celgene Corporation. AE is an employee of Health ResearchTx LLC, which has a business relationship with Celgene Corporation. SL, NM, SN and AL are employees of Celgene Corporation.
: This study was approved by the Naval Medical Center, Portsmouth, VA, institutional review board (IRB). All data derived from the Military Health System were de-identified prior to analysis and the research was conducted in compliance with federal and state laws, including the Health Insurance Portability and Accountability Act of 1996 (HIPAA) and Safe Harbor guidelines. This study is based in part on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare Products Regulatory Agency. The data are provided by patients and collected by the NHS as part of their care and support. This study was approved by the Independent Scientific Advisory Committee (ISAC) for Medicines and Healthcare Products Regulatory Agency database research (protocol no: 17_037RA), and the protocol was made available to the journal reviewers upon request. The ISAC protocol has been provided to the journal editors and is available to reviewers upon request. The HES Data Copyright © 2017 was re-used with the permission of The Health & Social Care Information Centre. All rights reserved. The ONS death registry data were re-used with the permission of The Health & Social Care Information Centre. All rights reserved. The interpretation and conclusions contained in this study are those of the author/s alone.