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Article History

Received: 21 February 2021

Revised: 8 June 2021

Accepted: 14 June 2021

First Online: 13 July 2021

Declarations

:

: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: IR has received research grants from the Orion Research Foundation sr, The Finnish Medical Foundation, The Finnish MS Foundation, and The Hospital District of South Ostrobothnia; received support for attending meetings and/or travel from Novartis, Sanofi Genzyme, and Teva; and will receive honoraria for serving as an investigator in an upcoming clinical trial from Sanofi. MU has participated in educational events or congresses sponsored by Biogen Idec, Merck, Novartis, Sanofi Genzyme, and Teva; and received honoraria for lectures or advisory boards from Biogen Idec, Merck, Novartis, Ratiopharm, Roche, Sanofi Genzyme, and Teva. MM has participated in educational events and congresses sponsored by Merck; and received honoraria for serving as an investigator in the Tysabri Observational Program from Biogen. AV-A has received investigator fees from Sanofi; and received congress fees or honoraria for lectures or advisory boards from Biogen, Merck, Novartis, Roche, Sanofi, and Orion. JTS has received speaker honoraria from Biogen-Idec, Merck, Novartis, Roche, Sanofi Genzyme, and Takeda; received reimbursement of travel expenses from Biogen-Idec, Merck, Roche, Sanofi Genzyme, Takeda, and Teva; participated in a scientific advisory board from Amicus, Actelion, Bayer, Biogen-Idec, Merck, Roche, and Sanofi Genzyme; and received research support from Bayer and Sanofi Genzyme. SS has received reimbursement of travel and accommodation expenses for educational events, received honoraria for lectures, advisory boards or for serving as an investigator for clinical trials from Allergan, Biogen, Merck, Novartis, Sanofi, and Teva. MR has received payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events from Alma Media, Duodecim, and Terve Media; received support for attending meetings and/or travel from Sanofi Genzyme; participated on a data safety monitoring board or advisory board from Biogen-Idec, Bristol-Myers Squibb, Celgene, Merck, Roche, and Sanofi Genzyme; and reports leadership or fiduciary role in other board, society, committee or advocacy group—paid or unpaid—from the Professional medical education society of Oulu, the Professional medical educational society of Finland, the Educational committee of Finnish neurology society, and Best Practice Nordic editorial. JOTS has received honoraria from Merck, Pfizer, and Sanofi; received consultancy fees from Rinnekoti Foundation and Medaffcon; received travel grants and congress sponsorship from Abbvie, Orion Pharma, Merck Serono, Sanquin, Lundbeck, and Novartis; and holds Orion Corporation shares. IP has received an honorarium for a lecture from Boehringer Ingelheim. HK has received honoraria for lectures, advisory boards or for serving as an investigator for clinical trials from Biogen, Celgene, Genzyme, Merck, Novartis, Roche, and Sanofi. TM, JMS, MK, LL, RA, TT, and AMR reported no conflicts of interest.

: This study was conducted retrospectively from data obtained for clinical purposes. According to local guidelines, a Research Ethics Committee approval was not required.

: Consent to participate was not required.

: Consent for publication was not required.