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Authors
Ellinghaus, Carla A. https://orcid.org/0009-0007-6790-656X
Röhling, Hanna M.
Dorsch, Eva-Maria
Sperber, Pia S.
Arsenova, Radina
Buenrostro, Gilberto Solorza
Rekers, Sophia
Usnich, Tatiana
Schindler, Patrick
Kroneberg, Daniel
Bellmann-Strobl, Judith
Oertel, Frederike C.
Brandt, Alexander U.
Weygandt, Martin
Paul, Friedemann
Piper, Sophie K.
Schmitz-Hübsch, Tanja
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Clinical Trials BETA
Clinical trials referenced in this document:
nct04993274 at ClinicalTrials.govDocuments that mention this clinical trial
Anchor-based evaluation of digital motor biomarkers from a 2-year observation in 100 patients with multiple sclerosis
https://doi.org/10.1007/s00415-025-13541-y
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Funding
Funding for this research was provided by:
Roche Pharma AG (ML40505)
Charité - Universitätsmedizin Berlin
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Article History
Received: 14 July 2025
Revised: 7 October 2025
Accepted: 22 November 2025
First Online: 4 December 2025
Declarations
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: HMR was a paid part-time employee at Motognosis GmbH until March 2023. TSM, FP, RA and JBS conducted and published a validated German translation of MSWS-12; however, there is no financial interest. The other authors declare that there are no competing interests.
: Written informed consent for participation was obtained from all participants for all studies prior to inclusion.
: Written informed consent includes publication of results in aggregated form, i.e. in a way that does not allow re-identification of individual participants for all studies.
: The study MOTOSENS (NCT04993274) was approved by the institutional review board (EA1/240/18, amendment 1) and conducted in accordance with the Declaration of Helsinki in its applicable version. Where available, data from the same individuals from observational studies (CIS EA1/182/10, ViMS EA1/163/12, BERLimmun EA1/362/20) using identical protocols were included to mitigate follow-up loss due to the COVID-19 pandemic (see Supplement and Supplementary Fig. ).
