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Authors
Kagaya, Risa
Sato, Noriko https://orcid.org/0000-0002-9305-7131
Saito, Yuko
Maki, Hiroyuki
Kan, Hirohito
Kimura, Yukio
Shigemoto, Yoko
Morita, Yuichi
Saito, Yoshito
Takahashi, Yuji
Tateishi, Ukihide
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (JP 24K10827)
Japan Society for the Promotion of Science (JP 22H04923)
Intramural Research Grant for Neurological and Psychiatric Disorders of the National Center of Neurology and Psychiatry (6-10)
Integrated Research Initiative for Living Well with Dementia (IRIDE) of the Tokyo Metropolitan Institute for Geriatrics and Gerontology IRIDE
Japan Agency for Medical Research and Development (JP24wm0425019)
Japan Agency for Medical Research and Development (JP24dk0207074h0001)
MHLW Research on rare and intractable diseases Program (JPMH23FC1008)
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Article History
Received: 23 October 2025
Revised: 12 February 2026
Accepted: 28 February 2026
First Online: 17 March 2026
Declarations
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: The authors declare no conflicts of interest directly relevant to the content of this article.
: This retrospective MR study was approved by the Ethics Committee of the National Center of Neurology and Psychiatry Hospital, Tokyo, Japan, with the requirement for informed consent waived. The Ethics Committee approval number is A2025-048. MRI data from the control group were also used, and secondary-use consent was obtained under Ethics Committee approval number A2023-045. As this was a prospected study, all participants provided written informed consent prior to participation.Autopsied brain tissue registration with the Brain Bank for Aging Research (BBAR) at the Tokyo Metropolitan Institute for Geriatrics and Gerontology was performed after informed consent was obtained from the next of kin. Its Brain Bank Ethics Committee approval number is 2005–16.
